CAJ | 학술논문

目的：探讨血清降钙素原(PCT)在恶性疟患者预后中的实验诊断价值。方法60例经厚血膜法和荧光定量PCR法确诊的恶性疟患者,采用全自动免疫荧光法测定PCT,同时测定相应的虫体密度,分析两者的相关性。结果①治疗前恶性疟虫体密度与PCT高度相关(r=0.90)。②轻度组、重度组和死亡组之间的PCT水平差异均有显著性(P<0.05),轻度组、重度组和死亡组之间的虫体密度差异均有显著性(P<0.05)。③伴随恶性疟病情加重,PCT增高,预后不良。结论 PCT可以作为恶性疟患者的有效治疗和预后的评价指标。
목적：탐토혈청강개소원(PCT)재악성학환자예후중적실험진단개치。방법60례경후혈막법화형광정량PCR법학진적악성학환자,채용전자동면역형광법측정PCT,동시측정상응적충체밀도,분석량자적상관성。결과①치료전악성학충체밀도여PCT고도상관(r=0.90)。②경도조、중도조화사망조지간적PCT수평차이균유현저성(P<0.05),경도조、중도조화사망조지간적충체밀도차이균유현저성(P<0.05)。③반수악성학병정가중,PCT증고,예후불량。결론 PCT가이작위악성학환자적유효치료화예후적평개지표。
Objective To explore the diagnostic value of the serum procalcitonin ( PCT) in patients with falciparum malaria. Method We used automatic immunofluorescence method to detect the PCT value of 60 patients with falcipa-rum, which were confirmed by thick film method and fluorescence quantitative PCR method. Besides, we detected the corresponding worm density and analyzed the correlation between PCT and worm density. Result①The worm density is highly correlated with PCT value before treatment. ②The PCT level is significant different in mild group, severe group and death group (P<0. 05). The worm density is also significant different in mild group, severe group and death group (P<0. 05).③PCT value is higher and the prognosis is poorer with the increase of malignant degree. Conclusion PCT can be used as an effective treatment and prognostic marker for falciparum malaria patients.