CAJ | 학술논문

目的：了解母婴同室新生儿皮肤感染金葡菌耐药状况，探讨其同源性，为指导临床治疗和预防控制感染提供依据。方法对北京市大兴区人民医院皮肤感染的新生儿皮损分泌物进行细菌培养、鉴定及药敏试验，应用脉冲场凝胶电泳方法进行基因分型。结果新生儿皮肤感染率为2.1％；金葡菌13株，占30.2％；头孢唑林、阿莫西林或克拉维酸及哌拉西林或他唑巴坦对金葡菌具有良好的抗菌活性。脉冲场凝胶电泳示H组与I组图谱完全相同。结论治疗新生儿金葡菌所致皮肤感染首选头孢类抗生素、阿莫西林或克拉维酸、哌拉西林或他唑巴坦；预防和控制其感染，须加强对新生儿皮肤和脐部的护理。
목적：료해모영동실신생인피부감염금포균내약상황，탐토기동원성，위지도림상치료화예방공제감염제공의거。방법대북경시대흥구인민의원피부감염적신생인피손분비물진행세균배양、감정급약민시험，응용맥충장응효전영방법진행기인분형。결과신생인피부감염솔위2.1％；금포균13주，점30.2％；두포서림、아막서림혹극랍유산급고랍서림혹타서파탄대금포균구유량호적항균활성。맥충장응효전영시H조여I조도보완전상동。결론치료신생인금포균소치피부감염수선두포류항생소、아막서림혹극랍유산、고랍서림혹타서파탄；예방화공제기감염，수가강대신생인피부화제부적호리。
Objective To investigate the antimicrobial resistance and homology analysis of Staphylococcus aureus ( S. aureus) isolated from with skin infections, thus to search for appropriate process to treat/prevent these skin disea-ses. Method Secretions of skin lesions from newborns with skin infections delivered in Obstetrics Department of Beijing Daxing People’s Hospital from Jan. 2012 to Jun. 2012 were collected,cultured and drug sensitivity test. Antibiotic resistances of S. aureus were determined. The genotype was detected with pulsed gel electrophoresis. Result Of 13 S. aureus isolated, the incidence was 30. 2%. Impetigo is the main disease of skin infection. S. au-reus was sensitive to cefazolin, amoxicillin/clavulanic acid and piperacillin/tazobactam. PFGE pattern of 13 strains showed 10 types, two type H and two type I which have the same pattern respectively. Conclusion The results sug-gest that effective clinical medication for skin and soft tissue infections caused by S. aureus are cefazolin, amoxicil-lin/clavulanic acid and piperacillin /tazobactam. It is important to disinfect all things the neonates may contact for preventing neonate infections caused by S. aureus.