疑难病杂志
疑難病雜誌
의난병잡지
JOURNAL OF DIFFICULT AND COMPLICATED CASES
2014年
11期
1114-1117
,共4页
喻小玲%周仕钧%彭海峰%杨旭波%唐海洋
喻小玲%週仕鈞%彭海峰%楊旭波%唐海洋
유소령%주사균%팽해봉%양욱파%당해양
脑卒中%肠内营养支持%营养状况%免疫功能%预后
腦卒中%腸內營養支持%營養狀況%免疫功能%預後
뇌졸중%장내영양지지%영양상황%면역공능%예후
Cerebral stroke%Enteral nutrition%Nutritional status%Immune function%Prognosis
目的:分析早期应用免疫肠内营养支持治疗对重症脑卒中患者营养状况、免疫功能及预后的影响。方法将66例重症脑卒中患者按数字表格法随机分为2组,每组33例。在常规治疗的基础上,对照组给予普通流质饮食鼻饲,观察组给予肠内营养支持治疗,治疗15 d后比较2组患者的营养情况、免疫功能及预后。结果治疗第15天,营养指标:对照组血清总蛋白(TP)、白蛋白(Alb)、前白蛋白(PA)、血红蛋白(Hb)分别为(61?.42±3.34)g/L、(34.04±3.92)g/L、(226.3±17.5)mg/L、(111.7±12.8)g/L,观察组分别为(67.16±4.41)g/L、(37.46±3.25)g/L、(278.6±16.1)mg/L、(127.4±13.3)g/L;免疫功能指标:对照组IgG、IgM、IgA、CD4、CD8、CD4/CD8分别为(13.04± 1.24)g/L、(1.78±0.43)g/L、(2.37±0.76) g/L、(36.92±1.94)%、(25.79±1.88)%、1.27±0.12;观察组分别为(16.49±1.16)g/L、(2.32±0.31)g/L、(2.84±0.53)g/L、(41.16±2.01)%、(27.84±1.93)%、1.56±0.19,2组患者各项指标均有降低,且对照组较观察组下降显著( P <0.05)。并发症:对照组患者肺部感染、心力衰竭、压疮、肾衰竭、尿路感染、应激性溃疡发生率分别为24.2%、18.2%、21.2%、15.2%、18.2%、36.4%,观察组分别为12.1%、9.1%、9.1%、6.1%、6.1%、24.2%,观察组低于对照组但差异无统计学意义( P >0.05)。结论应用早期肠内营养支持可明显改善重症脑卒中患者的预后,有效纠正低蛋白血症,提高机体免疫力,并减少并发症的发生。
目的:分析早期應用免疫腸內營養支持治療對重癥腦卒中患者營養狀況、免疫功能及預後的影響。方法將66例重癥腦卒中患者按數字錶格法隨機分為2組,每組33例。在常規治療的基礎上,對照組給予普通流質飲食鼻飼,觀察組給予腸內營養支持治療,治療15 d後比較2組患者的營養情況、免疫功能及預後。結果治療第15天,營養指標:對照組血清總蛋白(TP)、白蛋白(Alb)、前白蛋白(PA)、血紅蛋白(Hb)分彆為(61?.42±3.34)g/L、(34.04±3.92)g/L、(226.3±17.5)mg/L、(111.7±12.8)g/L,觀察組分彆為(67.16±4.41)g/L、(37.46±3.25)g/L、(278.6±16.1)mg/L、(127.4±13.3)g/L;免疫功能指標:對照組IgG、IgM、IgA、CD4、CD8、CD4/CD8分彆為(13.04± 1.24)g/L、(1.78±0.43)g/L、(2.37±0.76) g/L、(36.92±1.94)%、(25.79±1.88)%、1.27±0.12;觀察組分彆為(16.49±1.16)g/L、(2.32±0.31)g/L、(2.84±0.53)g/L、(41.16±2.01)%、(27.84±1.93)%、1.56±0.19,2組患者各項指標均有降低,且對照組較觀察組下降顯著( P <0.05)。併髮癥:對照組患者肺部感染、心力衰竭、壓瘡、腎衰竭、尿路感染、應激性潰瘍髮生率分彆為24.2%、18.2%、21.2%、15.2%、18.2%、36.4%,觀察組分彆為12.1%、9.1%、9.1%、6.1%、6.1%、24.2%,觀察組低于對照組但差異無統計學意義( P >0.05)。結論應用早期腸內營養支持可明顯改善重癥腦卒中患者的預後,有效糾正低蛋白血癥,提高機體免疫力,併減少併髮癥的髮生。
목적:분석조기응용면역장내영양지지치료대중증뇌졸중환자영양상황、면역공능급예후적영향。방법장66례중증뇌졸중환자안수자표격법수궤분위2조,매조33례。재상규치료적기출상,대조조급여보통류질음식비사,관찰조급여장내영양지지치료,치료15 d후비교2조환자적영양정황、면역공능급예후。결과치료제15천,영양지표:대조조혈청총단백(TP)、백단백(Alb)、전백단백(PA)、혈홍단백(Hb)분별위(61?.42±3.34)g/L、(34.04±3.92)g/L、(226.3±17.5)mg/L、(111.7±12.8)g/L,관찰조분별위(67.16±4.41)g/L、(37.46±3.25)g/L、(278.6±16.1)mg/L、(127.4±13.3)g/L;면역공능지표:대조조IgG、IgM、IgA、CD4、CD8、CD4/CD8분별위(13.04± 1.24)g/L、(1.78±0.43)g/L、(2.37±0.76) g/L、(36.92±1.94)%、(25.79±1.88)%、1.27±0.12;관찰조분별위(16.49±1.16)g/L、(2.32±0.31)g/L、(2.84±0.53)g/L、(41.16±2.01)%、(27.84±1.93)%、1.56±0.19,2조환자각항지표균유강저,차대조조교관찰조하강현저( P <0.05)。병발증:대조조환자폐부감염、심력쇠갈、압창、신쇠갈、뇨로감염、응격성궤양발생솔분별위24.2%、18.2%、21.2%、15.2%、18.2%、36.4%,관찰조분별위12.1%、9.1%、9.1%、6.1%、6.1%、24.2%,관찰조저우대조조단차이무통계학의의( P >0.05)。결론응용조기장내영양지지가명현개선중증뇌졸중환자적예후,유효규정저단백혈증,제고궤체면역력,병감소병발증적발생。
Ob jective To analyze the early applications of immune enteral nutrition support treatment effect on nutri -tional status, immune function and prognosis of patients with severe stroke .Methods Sixty-six cases of severe stroke patients were randomly divided into 2 groups by digital table method , 33 cases in each group .On the basis of conventional therapy , the control group was given common liquid diet feeding;the observation group was given enteral nutrition support treatment , im-mune function , nutritional condition and prognosis of the patients in the 2 groups after 15 d treatment were compared .Results On the fifteenth days of treatment, nutrition indicators revealed: serum total protein (TP), albumin (Alb), prealbumin (PA), hemoglobin (Hb) in control group were (61.42 ±3.34) g/L,(34.04 ±3.92) g/L,(226.3 ±17.5) mg/L,(111.7 ± 12.8) g/L, the observation group were (67.16 ±4.41) g/L,(37.46 ±3.25) g/L,(278.6 ±16.1) mg/L, (127.4 ±13.3) g/L;immune function index:control group’s IgG, IgM, IgA, CD4, CD8, CD4/CD8 were (13.04 ±1.24) g/L, (1.78 ± 0.43) g/L, (2.37 ±0.76) /L,(36.92 ±1.94)%, (25.79 ±1.88)%, (1.27 ±0.12);observation group were (16.49 ± 1.16) g/L, (2.32 ±0.31) g/L, (2.84 ±0.53) g/L, (41.16 ±2.01)%, (27.84 ±1.93)%, (1.56 ±0.19), the index of both groups were decreased, but in control group decreased significantly than those in the observation group (P <0.05). Complications:control group patients ’ pulmonary infection, heart failure, renal failure, pressure ulcers, urinary tract infec-tion, stress ulcer occurred rate were 24.2%, 18.2%, 21.2%, 15.2%, 18.2%, 36.4%, respectively, in the observation group were 12.1%, 9.1%, 9.1%, 6.1%, 6.1%, 24.2%, which were lower than that of control group , but no significant difference was observed between two groups ( P >0.05).Conclusion The application of early enteral nutrition support can improve the prognosis of patients with severe stroke , effective correct the hypoproteinemia , improve immunity, and reduce the complication.