CAJ | 학술논문

目的：评价自拟补肾活血方治疗冠心病PCI术后心绞痛的有效性和安全性。方法选择78例PCI术后心绞痛患者，采用随机数字表将研究对象分为对照组38例，给予冠心病PCI术后规范化治疗；治疗组40例，在对照组治疗的基础上加用自拟补肾活血方水煎剂200 ml／次，2次／d，观察心绞痛改善情况、中医临床证候积分变化及24 h动态心电图变化等。结果2组患者心绞痛症状改善总有效率比较差异有统计学意义（92？．5％ vs．65．4％， P ＜0．05）；2组临床中医证候积分与治疗前比较均明显下降，差异有统计学意义（ P ＜0．05），且治疗后治疗组较对照组下降更为显著（ P ＜0．05）；2组24 h动态心电图缺血发作次数、缺血总时间、缺血持续最长时间、室性早搏总数较治疗前均明显减少，差异有统计学意义（ P ＜0．05），且治疗后治疗组较对照组下降更为显著（ P ＜0．05）。且未发现与药物相关的不良反应。结论在规范化治疗基础上采用自拟补肾活血方治疗冠心病PCI术后心绞痛可提高临床疗效。
목적：평개자의보신활혈방치료관심병PCI술후심교통적유효성화안전성。방법선택78례PCI술후심교통환자，채용수궤수자표장연구대상분위대조조38례，급여관심병PCI술후규범화치료；치료조40례，재대조조치료적기출상가용자의보신활혈방수전제200 ml／차，2차／d，관찰심교통개선정황、중의림상증후적분변화급24 h동태심전도변화등。결과2조환자심교통증상개선총유효솔비교차이유통계학의의（92？．5％ vs．65．4％， P ＜0．05）；2조림상중의증후적분여치료전비교균명현하강，차이유통계학의의（ P ＜0．05），차치료후치료조교대조조하강경위현저（ P ＜0．05）；2조24 h동태심전도결혈발작차수、결혈총시간、결혈지속최장시간、실성조박총수교치료전균명현감소，차이유통계학의의（ P ＜0．05），차치료후치료조교대조조하강경위현저（ P ＜0．05）。차미발현여약물상관적불량반응。결론재규범화치료기출상채용자의보신활혈방치료관심병PCI술후심교통가제고림상료효。
Objective To evaluate the efficacy and safety of self-made Bushenhuoxue decoction in the treatment of angina pectoris post PCI .Methods Seventy-eight cases of patients with angina pectoris post PCI were enrolled , using the ran-dom number table , the subjects were divided into the control group with 38 cases, give the standardized treatment post PCI;the treatment group with 40 cases, based on the control group treatment , treated with self-made Bushenhuoxue decoction with 200 ml, 2 times a day, observe the changes of angina improvement , syndrome integral change and 24h dynamic electrocardio-gram etc..Results Two groups of patients ’ angina pectoris symptoms and the total efficiency of improvement revealed statis -tically significant differences (92.5%vs.65.4%, P <0.05);in the 2 groups, the clinical TCM syndrome score compared with before treatment, these indices were decreased significantly , the difference was statistically significant ( P <0.05), after treatment, the therapy group decreased significantly than the control group ( P <0.05) ;2 groups of 24 h dynamic ECG is-chemic attack times, total ischemia time, ischemia lasted long time, premature ventricular contractions were obviously de-creased than before treatment, the difference was statistically significant ( P <0.05), and after treatment, the treatment group decreased significantly than in the control group ( P <0.05).And no adverse reaction was found associated with drugs.Conclusion Based on the standardized treatment , use of self-effect of Bushenhuoxue in treating of angina pectoris after PCI can improve the clinical curative effect .