CAJ | 학술논문

目的：探讨Survivin基因在非霍奇金淋巴瘤组织中的表达及临床意义。方法：采用免疫组织化学方法检测非霍奇金淋巴瘤组织标本中的Survivin表达；采用Kaplan‐Meier生存曲线分析方式进行非霍奇金淋巴瘤患者Survival统计分析。结果：对照组人群中Survivin基因阳性表达反应率0．75％，显著低于惰性（15．73％）和侵袭性（54．01％）淋巴瘤患者Survivin阳性反应率；惰性淋巴瘤患者的Survivin阳性反应率也显著低于侵袭性淋巴瘤患者；Survivin在非霍奇金淋巴瘤组织的表达量与年龄、免疫表型、临床分期及发生部位等临床病理指标均无关，组内比较没有统计学差异；乳酸脱氢酶（LDH）≤250U／L的非霍奇金淋巴瘤患者组织Survivin阳性反应率（23．08％）显著低于LDH＞250U／L患者（48．65％）；Survivin阳性表达＞25％患者生存率显著低于Survivin阳性表达＜25％的患者。结论：Survivin可能会成为肿瘤早期诊断和预后预测的新肿瘤标志物。
목적：탐토Survivin기인재비곽기금림파류조직중적표체급림상의의。방법：채용면역조직화학방법검측비곽기금림파류조직표본중적Survivin표체；채용Kaplan‐Meier생존곡선분석방식진행비곽기금림파류환자Survival통계분석。결과：대조조인군중Survivin기인양성표체반응솔0．75％，현저저우타성（15．73％）화침습성（54．01％）림파류환자Survivin양성반응솔；타성림파류환자적Survivin양성반응솔야현저저우침습성림파류환자；Survivin재비곽기금림파류조직적표체량여년령、면역표형、림상분기급발생부위등림상병리지표균무관，조내비교몰유통계학차이；유산탈경매（LDH）≤250U／L적비곽기금림파류환자조직Survivin양성반응솔（23．08％）현저저우LDH＞250U／L환자（48．65％）；Survivin양성표체＞25％환자생존솔현저저우Survivin양성표체＜25％적환자。결론：Survivin가능회성위종류조기진단화예후예측적신종류표지물。
objective:To evaluate the role of Survivin gene in the expression and clinical significance of non‐hodgkin's lymphoma tissue .Methods :Using immunohistochemical methods expression of survivin in non‐hodgkin's lymphoma tissue samples ;Using Kaplan Meier survival curve analysis method for non‐hodgkin's lymphoma patients survival statistics analysis .Results :In the control group in the crowd ,survivin gene expression positive re‐sponse rate was 0 .75% lower than inert (15 .73% ) and invasive survivin positive response rate (54 .01% ) lymphoma patients ;Survivin positive reaction rate of inert lymphoma patients was also significantly lower than that of invasive lymphoma patients .The expression of survivin in non‐hodgkin's lymphoma tissue volume and age ,the immune phe‐notype ,clinical stage and clinical pathological indexes ,such as parts within the group no statistical difference ,lac‐tate dehydrogenase (LDH ) of 250 U/L or less patients with non‐hodgkin's lymphoma tissue survivin positive re‐sponse rate (23 .08% ) were significantly lower than that in LDH > 250 U/L patients (48 .65% ) .Survivin positive expression of > 25% of patients survival rate was significantly lower than Survivin positive expression of < 25% of the patients .Conclusion :Survivin may be a tumor early diagnosis and prognosis prediction of new tumor markers .