CAJ | 학술논문

目的探讨氧疗对移居海拔3700 m高原人体缺氧损伤的预防作用。方法对海拔3700 m居住1年以上的120名男性青年随机分为A组（吸氧30 min/d，n=40）、B组（吸氧1 h/d，n=40）、C组（不吸氧，n=40），吸氧流量为2 L/min，连续吸氧30 d。检测吸氧前、吸氧15 d、30 d和停氧15 d慢性高原病（ CMS）症状评分、睡眠质量评分、血红蛋白（ Hb）浓度、HR、血压、呼吸频率、SaO2和1000 m跑成绩。结果 B组吸氧15 d和30 d时与吸氧前比较，睡眠质量评分降低（ P<0.05 or P<0.01）。A组与B组比较，吸氧15 d和30 d时的CMS症状评分、睡眠质量评分均降低（ P<0.05或P<0.01）；A组、B组吸氧30 d时和与吸氧前比较，SaO2均升高（ P<0.01）。A组、B组与C组比较，吸氧15 d、30 d及停氧15 d时，CMS症状评分降低、Hb浓度降低、SaO2升高（P<0.05或P<0.01）。结论长期低浓度氧疗，可预防慢性高原病，改善高原睡氧眠质量，稳定或减轻Hb浓度增加。每天吸氧1 h要优于30 min。停止吸氧15 d后，生理指标恢复到吸氧前的水平。
목적탐토양료대이거해발3700 m고원인체결양손상적예방작용。방법대해발3700 m거주1년이상적120명남성청년수궤분위A조（흡양30 min/d，n=40）、B조（흡양1 h/d，n=40）、C조（불흡양，n=40），흡양류량위2 L/min，련속흡양30 d。검측흡양전、흡양15 d、30 d화정양15 d만성고원병（ CMS）증상평분、수면질량평분、혈홍단백（ Hb）농도、HR、혈압、호흡빈솔、SaO2화1000 m포성적。결과 B조흡양15 d화30 d시여흡양전비교，수면질량평분강저（ P<0.05 or P<0.01）。A조여B조비교，흡양15 d화30 d시적CMS증상평분、수면질량평분균강저（ P<0.05혹P<0.01）；A조、B조흡양30 d시화여흡양전비교，SaO2균승고（ P<0.01）。A조、B조여C조비교，흡양15 d、30 d급정양15 d시，CMS증상평분강저、Hb농도강저、SaO2승고（P<0.05혹P<0.01）。결론장기저농도양료，가예방만성고원병，개선고원수양면질량，은정혹감경Hb농도증가。매천흡양1 h요우우30 min。정지흡양15 d후，생리지표회복도흡양전적수평。
Objective To explore the prevention of oxygen therapy from hypoxic injury in migrators at 3700 m high altitude. Methods Total 120 young males who had lived in 3700 m high altitude above sea level for more than one year were selected and divided randomly into group A(inhaling oxygen for 30 min per day,n=40),group B(inhaling oxygen for one hour per day,n=40), and group C( no oxygen inhalation,n=40 ). The oxygen flow rate was two liters per minute and the inhaling time was 30 consecutive days. Chronic mountain sickness( CMS )symptom scores,sleep quality score,hemoglobin( Hb )concentration,HR,blood pressure, respiratory rate,SaO2 and performance in 1000 m run were examined and evaluated before the oxygen inhalation,after 15 day and 30 day oxygen inhalation,and after oxygen inhalation had been stopped for 15 days,respectively. Results The sleep quality score of the subjects in group B after 15 day and 30 day oxygen inhalations was lower than that before the oxygen inhalation( P <0. 05 or P<0. 01). The CMS symptom score and sleep quality score of the subjects in group A after 15 day and 30 day oxygen inhalations were lower than that in group B(P<0. 05 or P<0. 01);SaO2 of the subjects in both group A and B increased after 30 day oxygen inhalation in comparison with that before the oxygen inhalation(P<0. 01). Besides,in comparison with group C,the CMS symptom score and Hb concentration of both group A and B decreased but SaO2 increased after 15 day and 30 day oxygen inhalations and after oxygen inhalation had been stopped for 15 days(P<0. 05 or P<0. 01). Conclusion Long-term low-concentration oxygen therapy can prevent chronic mountain sickness,improve sleep quality,stabilize or reduce the increase of Hb concentration. The effect of oxygen inhalation for one hour every day will be better than that for 30 minutes. After oxygen inhalation is stopped for 15 days,the physiological indexes will recover to the level before the oxygen inhalation.