CAJ | 학술논문

目的探讨吡格列酮治疗青春期多囊卵巢综合征（ PCOS）的疗效和安全性。方法我院妇科门诊就诊的青春期PCOS患者62例，随机分为吡格列酮组和二甲双胍组，每组各31例。两组均接受生活干预和抗雄激素治疗，治疗24 w后，比较分析两组间的疗效和安全性。结果治疗后，两组在恢复正常月经和排卵、降低雄激素水平、抑制黄体生成素（ LH）、升高孕酮（ P）、降低高胰岛素水平和降低三酰甘油（ TG）及低密度脂蛋白（ LDL）水平上疗效相当；治疗后，二甲双胍组卵泡刺激素（ FSH）和泌乳素（ PRL）水平较吡格列酮组高。但吡格列酮组不良反应较少。结论在改善生活方式和抗雄激素治疗基础上，加用吡格列酮治疗青春期PCOS的疗效与加用二甲双胍的疗效相当，安全性好。
목적탐토필격렬동치료청춘기다낭란소종합정（ PCOS）적료효화안전성。방법아원부과문진취진적청춘기PCOS환자62례，수궤분위필격렬동조화이갑쌍고조，매조각31례。량조균접수생활간예화항웅격소치료，치료24 w후，비교분석량조간적료효화안전성。결과치료후，량조재회복정상월경화배란、강저웅격소수평、억제황체생성소（ LH）、승고잉동（ P）、강저고이도소수평화강저삼선감유（ TG）급저밀도지단백（ LDL）수평상료효상당；치료후，이갑쌍고조란포자격소（ FSH）화비유소（ PRL）수평교필격렬동조고。단필격렬동조불량반응교소。결론재개선생활방식화항웅격소치료기출상，가용필격렬동치료청춘기PCOS적료효여가용이갑쌍고적료효상당，안전성호。
Objective To explore the efficacy and safety of pioglitazone in the treatment of adolescent polycystic ovary syndrome( PCOS). Methods Total 62 adolescent PCOS patients receiving treatment in Department of Gynecology of our hospital were selected and divided randomly into pioglitazone group and metformin group,31 ones in each group. The patients in both groups received life intervention and anti-androgen therapy. Furthermore,the patients received pioglitazone or metformin treatment according to their grouping. After 24 weeks of treatment,the efficacy and safety between the two groups were compared and analyzed. Results After the treatment,the efficiencies of both groups were equivalent in the restoration of normal menstruation and ovulation,reduction of androgen levels,inhibition of luteinizing hormone(LH),increase of progesterone(P),and reduction of high insulin levels,triglyceride(TG)and low density lipoprotein( LDL)levels;the metformin group had higher follicle stimulating hormone( FSH)and prolactin( PRL)levels than the pioglitazone group which had less adverse reactions. Conclusion On the basis of improvement of life style and anti-androgen therapy,additional administration of pioglitazone or metformin in the treatment of adolescent PCOS has equivalent efficiency and safety.