西南国防医药
西南國防醫藥
서남국방의약
MEDICAL JOURNAL OF NATIONAL DEFENDING FORCES IN SOUTHWEST CHINA
2014年
11期
1186-1188
,共3页
刘爱东%宋旭东%李双%熊艳杰%张宏伟%李倩%王献华
劉愛東%宋旭東%李雙%熊豔傑%張宏偉%李倩%王獻華
류애동%송욱동%리쌍%웅염걸%장굉위%리천%왕헌화
胃腺癌%nm23%P53%Ki67%免疫组化
胃腺癌%nm23%P53%Ki67%免疫組化
위선암%nm23%P53%Ki67%면역조화
gastric adenocarcinoma%nm23%P53%Ki67%immunohistochemistry
目的检测胃腺癌中nm23、P53和Ki67增殖指数的关系，分析其临床意义。方法以2010年3月~2013年6月我院收治的84例胃腺癌存档的蜡块组织作为观察组，选择45例正常胃黏膜组织作为对照组，应用免疫组化方法检测两组中nm23、P53和Ki67的表达水平；以阳性率为计数指标，结合患者临床资料，分析3种蛋白在肿瘤中表达的意义。结果观察组nm23表达的阳性率明显低于对照组，P53和Ki67表达的阳性率明显高于对照组（ P<0.01）；观察组nm23的表达与肿瘤的分化程度、浸润深度和有无癌栓密切相关，P53的表达与肿瘤的淋巴结检出数量、浸润深度、肿瘤的最大径和分化程度密切相关，Ki67的表达与浸润深度和肿瘤的最大径密切相关（ P<0.05或P<0.01）。线性相关性分析显示，观察组nm23与P53、nm23与Ki67、P53与Ki67之间的表达均具有相关性。结论胃腺癌中nm23低表达、P53和Ki67高表达不仅可以促进肿瘤的发生，还可以促进肿瘤的进展，nm23和P53与Ki67的表达具有相关性。
目的檢測胃腺癌中nm23、P53和Ki67增殖指數的關繫，分析其臨床意義。方法以2010年3月~2013年6月我院收治的84例胃腺癌存檔的蠟塊組織作為觀察組，選擇45例正常胃黏膜組織作為對照組，應用免疫組化方法檢測兩組中nm23、P53和Ki67的錶達水平；以暘性率為計數指標，結閤患者臨床資料，分析3種蛋白在腫瘤中錶達的意義。結果觀察組nm23錶達的暘性率明顯低于對照組，P53和Ki67錶達的暘性率明顯高于對照組（ P<0.01）；觀察組nm23的錶達與腫瘤的分化程度、浸潤深度和有無癌栓密切相關，P53的錶達與腫瘤的淋巴結檢齣數量、浸潤深度、腫瘤的最大徑和分化程度密切相關，Ki67的錶達與浸潤深度和腫瘤的最大徑密切相關（ P<0.05或P<0.01）。線性相關性分析顯示，觀察組nm23與P53、nm23與Ki67、P53與Ki67之間的錶達均具有相關性。結論胃腺癌中nm23低錶達、P53和Ki67高錶達不僅可以促進腫瘤的髮生，還可以促進腫瘤的進展，nm23和P53與Ki67的錶達具有相關性。
목적검측위선암중nm23、P53화Ki67증식지수적관계，분석기림상의의。방법이2010년3월~2013년6월아원수치적84례위선암존당적사괴조직작위관찰조，선택45례정상위점막조직작위대조조，응용면역조화방법검측량조중nm23、P53화Ki67적표체수평；이양성솔위계수지표，결합환자림상자료，분석3충단백재종류중표체적의의。결과관찰조nm23표체적양성솔명현저우대조조，P53화Ki67표체적양성솔명현고우대조조（ P<0.01）；관찰조nm23적표체여종류적분화정도、침윤심도화유무암전밀절상관，P53적표체여종류적림파결검출수량、침윤심도、종류적최대경화분화정도밀절상관，Ki67적표체여침윤심도화종류적최대경밀절상관（ P<0.05혹P<0.01）。선성상관성분석현시，관찰조nm23여P53、nm23여Ki67、P53여Ki67지간적표체균구유상관성。결론위선암중nm23저표체、P53화Ki67고표체불부가이촉진종류적발생，환가이촉진종류적진전，nm23화P53여Ki67적표체구유상관성。
Objective To study the relationship of the expression of nm23 and P53 with Ki67 proliferation index in gastric adenocarcinoma and analyze the clinical value. Methods The archived wax block tissues of 84 patients receiving treatment in our hospital from Mar. of 2010 to Jun. of 2013 for their gastric adenocarcinoma were selected as the observation group,and the normal gastric mucosa tissues of 45 patients of 84 ones were selected as the control group. Immunohistochemical method was used to detect the expression level of nm23,P53 and Ki67 of the patients in the two groups. Positive rate being taken as the estimated index,the expressed significances of the three proteins in tumors were analyzed in combination with clinical data. Results The expressed positive rate of nm23 in the observation group was significantly lower than that in the control group,and the expressed positive rates of P53 and Ki67 were significantly higher than those in the control group(P<0. 01);in the observation group,the expression of nm23 was closely related with the degree of differentiation and depth of infiltration of the tumor as well as the existence of cancerous thrombus,the expression of P53 was closely related with the detected counts of lymph node of tumor,the depth of infiltration,the maximum tumor size,and the degree of differentiation,and the expression of Ki67 was closely related with the depth of infiltration and the maximum tumor size( P<0. 05 or P<0. 01). Linear correlation analysis showed that there were linear correlations between the expressions of nm23 and P53, between nm23 and Ki67,as well as between P53 and Ki67 in the observation group. Conclusion Low expression level of nm23 and high expression level of P53 and Ki67 in patients with gastric adenocarcinoma will promote the occurrence and development of tumors, and nm23 and P53 have synergetic effects on the expression of Ki67.
