CAJ | 학술논문

目的：探讨左旋-二脱水伊地醇双甲磺酸酯含药血清对 HL-60细胞的增殖抑制作用。方法运用CCK-8法测定不同剂量组DMDAI-L的含药血清对HL-60细胞的增殖影响。结果 DMDAI-L高中低剂量组含药血清作用 HL -60细胞48 h 抑制率分别为30.29%、20.72%、13.97%，而阳性组（环磷酰胺）抑制率为18.16%，高、中、低剂量组、阳性对照组与空白对照组比较有显著性差异（ P<0.05）。结论 DMDAI-L含药血清能够有效抑制HL-60细胞增殖。
목적：탐토좌선-이탈수이지순쌍갑광산지함약혈청대 HL-60세포적증식억제작용。방법운용CCK-8법측정불동제량조DMDAI-L적함약혈청대HL-60세포적증식영향。결과 DMDAI-L고중저제량조함약혈청작용 HL -60세포48 h 억제솔분별위30.29%、20.72%、13.97%，이양성조（배린선알）억제솔위18.16%，고、중、저제량조、양성대조조여공백대조조비교유현저성차이（ P<0.05）。결론 DMDAI-L함약혈청능구유효억제HL-60세포증식。
Objective To detect the effect of serum containing DMDAI-L on human myeloid leukemia HL-60 cells. MetHods The proliferation inhibitory effect of serum containing DMDAI-L on human myeloid leukemia HL-60 cells were detected by CCK-8 assay in vitro. Results The high,medium and low-dose groups of serum containing DMDAI-L can inhibit the growth of HL -60 cells,the inhibition rate of high,medium and low -dose groups for 48 hours were 30. 29%,20. 72%,13. 97%and cyclophosphamide group was 18. 16%,there was significantly difference related to the con-trol group(P<0. 05). CoNclusioN The serum containing DMDAI-L can inhibit the growth of HL-60 cells effectively.