CAJ | 학술논문

细胞中的非编码单链小分子RNA,通过对mRNA的降解和翻译抑制调控基因表达。 MicroRNAs作为癌基因或抑癌基因,可直接参与RB的发生、发展,并在RB的早期诊断和临床靶向治疗中具有重要作用。本文主要对近年来RB中microRNAs的表达情况以及其在RB形成中的作用机制的研究进行简要综述。
세포중적비편마단련소분자RNA,통과대mRNA적강해화번역억제조공기인표체。 MicroRNAs작위암기인혹억암기인,가직접삼여RB적발생、발전,병재RB적조기진단화림상파향치료중구유중요작용。본문주요대근년래RB중microRNAs적표체정황이급기재RB형성중적작용궤제적연구진행간요종술。
Retinoblastoma(RB)is the most common intraocular malignancy of children with extremely poor prognosis. MicroRNAs are small non-coding single-stranded RNAs in eukaryotic cells, which regulate the expression of gene by mRNA degradation or translation inhibition. MicroRNAs, acting as oncogenes or tumor suppressor genes, are associated with the occurrence and development of RB directly, which is vital for the early diagnosis and clinical targeted therapy of RB. This review summarized the expression of microRNAs in RB and the related mechanism.