国际眼科杂志
國際眼科雜誌
국제안과잡지
INTERNATIONAL JOURNAL OF OPHTHALMOLOGY
2014年
11期
1943-1945
,共3页
秦裕辉%李文娟%张熙%戴宗顺%陈晓柳%周亚莎%凌艳君%郑兵
秦裕輝%李文娟%張熙%戴宗順%陳曉柳%週亞莎%凌豔君%鄭兵
진유휘%리문연%장희%대종순%진효류%주아사%릉염군%정병
糖尿病视网膜病变%双丹明目胶囊%血糖%视网膜%胰腺
糖尿病視網膜病變%雙丹明目膠囊%血糖%視網膜%胰腺
당뇨병시망막병변%쌍단명목효낭%혈당%시망막%이선
diabetic retinopathy%Shuangdanmingmu capsule%blood glucose%retina%pancreas
目的：通过建立大鼠糖尿病视网膜病变( diabetic retinopathy,DR)模型,观察造模后大鼠的血糖以及视网膜和胰腺组织的病理变化,初步评价双丹明目胶囊对改善DR视网膜和胰腺组织结构的效应。
<br> 方法：将双丹明目胶囊作用于DR大鼠,通过与正常组、模型对照组、阳性对照组的比较,观察双丹明目胶囊对DR大鼠视网膜和胰腺形态学的影响。
<br> 结果：经双丹明目胶囊治疗2 mo后,双丹明目组大鼠血糖和糖化血红蛋白与模型对照组比较均明显降低,血糖差异有显著意义(P<0.01)。双丹明目组病变较模型对照组轻,光感受器细胞层排列基本整齐,各层组织细胞内、细胞外水肿现象较模型对照组轻,毛细血管管腔无闭塞,周细胞轻度水肿。
<br> 结论：双丹明目胶囊能有效降低DR大鼠血糖和糖化血红蛋白含量。双丹明目胶囊能有效改善DR大鼠视网膜和胰腺组织结构。
目的：通過建立大鼠糖尿病視網膜病變( diabetic retinopathy,DR)模型,觀察造模後大鼠的血糖以及視網膜和胰腺組織的病理變化,初步評價雙丹明目膠囊對改善DR視網膜和胰腺組織結構的效應。
<br> 方法：將雙丹明目膠囊作用于DR大鼠,通過與正常組、模型對照組、暘性對照組的比較,觀察雙丹明目膠囊對DR大鼠視網膜和胰腺形態學的影響。
<br> 結果：經雙丹明目膠囊治療2 mo後,雙丹明目組大鼠血糖和糖化血紅蛋白與模型對照組比較均明顯降低,血糖差異有顯著意義(P<0.01)。雙丹明目組病變較模型對照組輕,光感受器細胞層排列基本整齊,各層組織細胞內、細胞外水腫現象較模型對照組輕,毛細血管管腔無閉塞,週細胞輕度水腫。
<br> 結論：雙丹明目膠囊能有效降低DR大鼠血糖和糖化血紅蛋白含量。雙丹明目膠囊能有效改善DR大鼠視網膜和胰腺組織結構。
목적：통과건립대서당뇨병시망막병변( diabetic retinopathy,DR)모형,관찰조모후대서적혈당이급시망막화이선조직적병리변화,초보평개쌍단명목효낭대개선DR시망막화이선조직결구적효응。
<br> 방법：장쌍단명목효낭작용우DR대서,통과여정상조、모형대조조、양성대조조적비교,관찰쌍단명목효낭대DR대서시망막화이선형태학적영향。
<br> 결과：경쌍단명목효낭치료2 mo후,쌍단명목조대서혈당화당화혈홍단백여모형대조조비교균명현강저,혈당차이유현저의의(P<0.01)。쌍단명목조병변교모형대조조경,광감수기세포층배렬기본정제,각층조직세포내、세포외수종현상교모형대조조경,모세혈관관강무폐새,주세포경도수종。
<br> 결론：쌍단명목효낭능유효강저DR대서혈당화당화혈홍단백함량。쌍단명목효낭능유효개선DR대서시망막화이선조직결구。
AIM: To observe pathological changes of blood glucose, the retina and pancreatic tissue after establishing rats diabetic retinopathy ( DR) model, and preliminary evaluate of Shuangdanmingmu capsule on the improvement of retina and pancreas tissue structure.METHODS: DR rats were fed with Shuangdanmingmu capsule. Then the blood glucose and glycated hemoglobin were determined. Immunohitochemical staining was used to observe the expression of structure of retino and pancreas.
<br> RESULTS:Compared with the control group, the blood glucose and glycates hemoglobin in Shuangdanmingmu group were decreased after 2mo of treatment (P<0. 01). The layers tissue of retina was less edema and gradually arranged in Shuangdanmingmu group. The structure of pancreas was clear basically. Fat cells, infiltrati on of lymphocytes and fibrosis hyperplasia appeared in the interacinar and interlobular connective tissue. Some acinar and islet cells of fatty rat pancreatic tissue had fatty or vesicular degeneration.
<br> CONCLUSION: Shuangdanmingmu capsule can decrease blood glucose and glycates hemoglobin in DR rats effectively and improve the ultrastructure of retina and pancreas tissue.
