CAJ | 학술논문

来氟咪特是一种抗增殖类的免疫抑制剂，主要作用机制为阻断嘧啶的从头合成，是临床治疗多种免疫介导性肾脏病的有效药物。近年来，基础研究结果发现来氟咪特还具有抗病毒和足细胞保护的作用，随着对其作用机制的深入研究，来氟咪特在糖尿病肾病、多瘤病毒相关性肾病和肝炎病毒相关性肾炎等的治疗中表现出独特的作用。此外，由于来氟咪特的治疗安全有效且价格适中也成为免疫抑制剂联合应用的有利选择。
래불미특시일충항증식류적면역억제제，주요작용궤제위조단밀정적종두합성，시림상치료다충면역개도성신장병적유효약물。근년래，기출연구결과발현래불미특환구유항병독화족세포보호적작용，수착대기작용궤제적심입연구，래불미특재당뇨병신병、다류병독상관성신병화간염병독상관성신염등적치료중표현출독특적작용。차외，유우래불미특적치료안전유효차개격괄중야성위면역억제제연합응용적유리선택。
Leflunomide is a kind of anti-proliferation immunosuppressive agent,whose main mechanism is blocking the de novo synthesis of pyrimidines,and is an effective drug for the clinical treatment of various immune-mediated kidney diseases.Besides,in recent years,results of basic researches have disclosed that leflunomide has antiviral and podocyte-protective effects.Leflunomide has also proved to have special effects in the treatment of diabetic nephropathy,polyomavirus-associated nephropathy,and hepatitis B virus-associated glomerulonephritis.The reason that leflunomide is both safe and effective with affordable price has made leflunomide a preferred choice for combined application of immunosuppressants.