CAJ | 학술논문

目的：比较两种方案治疗局部晚期非鳞非小细胞肺癌副反应及近期疗效。方法回顾2009年3月—2013年1月42例局部晚期非鳞非小细胞肺癌患者，所有患者均接受同步放化疗，A组放疗同步培美曲塞＋顺铂化疗，B组放疗同步多西他赛＋顺铂化疗，比较A、B两组患者副反应及近期疗效。结果 A组28例患者，B组14例患者，两组副反应比较，血液毒性：白细胞减少、中性粒细胞减少、血色素降低、血小板减少无统计学差异（ P＞0．05）。非血液毒性：放射性肺损伤发生率、咳嗽发生率B组明显高于A组，有统计学差异（P＜0．05）。而其他非血液毒性：肝功能损伤、肾功能损伤、发热、呼吸困难、放射性食管炎、乏力、体重下降、消化道反应、皮肤反应均无统计学差异（P＞0．05）。近期疗效：A、B两组有效率分别为75％及71．43％，无统计学差异（P＞0．05）。结论放疗同步培美曲塞＋顺铂化疗与同步多西他塞＋顺铂化疗的两组疗效无显著差异，但培美曲塞在治疗局部晚期非鳞非小细胞肺癌副反应方面存在一定优势。
목적：비교량충방안치료국부만기비린비소세포폐암부반응급근기료효。방법회고2009년3월—2013년1월42례국부만기비린비소세포폐암환자，소유환자균접수동보방화료，A조방료동보배미곡새＋순박화료，B조방료동보다서타새＋순박화료，비교A、B량조환자부반응급근기료효。결과 A조28례환자，B조14례환자，량조부반응비교，혈액독성：백세포감소、중성립세포감소、혈색소강저、혈소판감소무통계학차이（ P＞0．05）。비혈액독성：방사성폐손상발생솔、해수발생솔B조명현고우A조，유통계학차이（P＜0．05）。이기타비혈액독성：간공능손상、신공능손상、발열、호흡곤난、방사성식관염、핍력、체중하강、소화도반응、피부반응균무통계학차이（P＞0．05）。근기료효：A、B량조유효솔분별위75％급71．43％，무통계학차이（P＞0．05）。결론방료동보배미곡새＋순박화료여동보다서타새＋순박화료적량조료효무현저차이，단배미곡새재치료국부만기비린비소세포폐암부반응방면존재일정우세。
[Abstrct] Objective To compare the short -term tumor response and adverse events of two chemoradio-therapy regimens for locally advanced non -squamous non-small cell lung cancer .Methods From March 2009 to January 2013 ,we recruited 42 patients with stage ⅢNSCLC who had received three -dimensional intensity -modulated radiotherapy combined with chemotherapy .group A treated with radiotherapy combined pemetrexed plus cisplatin and group B treated with radiotherapy combined docetaxel plus cisplatin .We compared the short -term tumor response and adverse events between the two regimens .Results There were 28 cases in group A and 14 cases in group B .There were no significant differences between the two groups in hematologic toxicities ,such as leukopenia,neutropenia,anemia and thrombocytopenia.In non-hematologic toxicities,radiation pneumonitis and cough were no significances respectively (P<0.05).There were no significant differences in other non -he-matologic toxicities,such as liver dysfunction,renal dysfunction,fever,dyspnea,radiation esophagitis,hypody-namia,weight loss,gastrointestinal reactions and skin reactions .The response rate displayed no differences be-tween two groups .Conclusion This study reveals Pemetrexed plus cisplatin group had less non -hematologic toxicities than Docetaxel plus cisplatin group in locally advanced non -squamous non -small cell lung cancer . But there are no differences in the short -term tumor response between the two regimens .