CAJ | 학술논문

目的：探讨应用平阳霉素化疗对阴茎癌组织蛋白c－myc、Ras－P21表达的影响及意义。方法收集1995—2005年间阴茎鳞状细胞癌患者100例，按照术前是否进行化疗分为两组，其中化疗组50例，术前应用平阳霉素化疗7天，并在化疗后行阴茎部分切除术＋改良方法的腹股沟淋巴结清扫术；对照组50例，未进行化疗而直接行阴茎部分切除术改良方法的腹股沟淋巴结清扫术。应用免疫组化法（ SP）对两组的100例阴茎癌组织标本进行c－myc、Ras－P21蛋白产物检测。应用χ2检验对数据进行统计分析。结果化疗组50例阴茎癌标本中c－myc、Ras－P21表达阳性率分别为30％、27％。对照组50例阴茎癌标本中，c－myc、Ras－P21表达阳性率分别为52％、48％。经χ2检验，化疗组与对照组的c－myc、Ras－P21表达阳性率的差异具有统计学意义（P＜0．05）。结论应用平阳霉素化疗后阴茎癌组织中c－myc、Ras－P21蛋白的表达明显下降。
목적：탐토응용평양매소화료대음경암조직단백c－myc、Ras－P21표체적영향급의의。방법수집1995—2005년간음경린상세포암환자100례，안조술전시부진행화료분위량조，기중화료조50례，술전응용평양매소화료7천，병재화료후행음경부분절제술＋개량방법적복고구림파결청소술；대조조50례，미진행화료이직접행음경부분절제술개량방법적복고구림파결청소술。응용면역조화법（ SP）대량조적100례음경암조직표본진행c－myc、Ras－P21단백산물검측。응용χ2검험대수거진행통계분석。결과화료조50례음경암표본중c－myc、Ras－P21표체양성솔분별위30％、27％。대조조50례음경암표본중，c－myc、Ras－P21표체양성솔분별위52％、48％。경χ2검험，화료조여대조조적c－myc、Ras－P21표체양성솔적차이구유통계학의의（P＜0．05）。결론응용평양매소화료후음경암조직중c－myc、Ras－P21단백적표체명현하강。
Objective To evaluate the influence and significance of Pingyangmycin chemotherapy on the c-myc and Ras-P21 protein expression in penile cancer .Methods A total of 100 penile squamous cell carci-noma cases was retrospectively studied and divided into two groups .Data were obtained from 1995 to 2005 .In the chemotherapy group ,50 cases of patients were selected to perform preoperative chemotherapy before surgery .The patients were treated by Pingyangmycin .After 7 times of medication ,partial excision of penis plus improved ingui-nal lymph node dissection was performed .In the control group ,50 cases of patients were selected for partial exci-sion of penis plus improved inguinal lymph node dissection directly without any pre -operative chemotherapy .All pathology specimens were detected of c -myc and Ras-P21 protein expression by immunohistochemical staining assay.Theχ2 test was used for the statistical analysis .Results In chemotherapy group,the positive expression rates of c-myc and Ras-P21 were 30%,27%,respectively.However,in control group,the positive expression rate of c-myc,Ras-P21 were 52%,48%,respectively.By theχ2 test,the expressive differences of c -myc,Ras-P21 positive expression rate between chemotherapy group and control group were all significant (P<0.05). Conclusion The protein expressions of c -myc and Ras-P21 is significantly decreased in the tissue of Pingy-angmycin chemotherapy of penile cancer .