CAJ | 학술논문

目的：探讨绝经后女性乳腺癌的发病与血清性激素水平和体重指数的关系。方法选择2013年3月—12月在哈尔滨医科大学附属肿瘤医院乳腺外科接受手术治疗的初诊绝经后乳腺癌118例作为病例组以及60例绝经后乳腺良性病变者作为对照组，并收集所有受试对象的身高、体重等基本资料。应用酶联免疫吸附实验（ELISA）方法检测受试对象的血清雌二醇（Estradiol，E2）、雌酮（Estrone，E1）、睾酮（Testesterone，TSTO）以及雄烯二酮（Androstenedione，AED）水平，并对结果进行分析。结果病例组血清E2、E1、AED水平显著高于对照组（ P＜0．05），病例组的血清TSTO平均水平稍高于对照组，但差异无统计学意义（P＞0．05）；病例组体重指数（BMI）与对照组无明显差异（P＞0．05）；病例组血清E1以及总研究对象的血清E1、TSTO、AED在超重组内的水平明显高于非超重组（P＜0．05），未发现其余各组的激素水平与BMI指数具有相关性（P＞0．05）。结论绝经后女性乳腺癌患者的血清性激素水平升高，血清E2、E1、AED水平升高可能是与绝经后女性乳腺癌的发病相关，BMI高的绝经后女性的血清性激素水平较高。
목적：탐토절경후녀성유선암적발병여혈청성격소수평화체중지수적관계。방법선택2013년3월—12월재합이빈의과대학부속종류의원유선외과접수수술치료적초진절경후유선암118례작위병례조이급60례절경후유선량성병변자작위대조조，병수집소유수시대상적신고、체중등기본자료。응용매련면역흡부실험（ELISA）방법검측수시대상적혈청자이순（Estradiol，E2）、자동（Estrone，E1）、고동（Testesterone，TSTO）이급웅희이동（Androstenedione，AED）수평，병대결과진행분석。결과병례조혈청E2、E1、AED수평현저고우대조조（ P＜0．05），병례조적혈청TSTO평균수평초고우대조조，단차이무통계학의의（P＞0．05）；병례조체중지수（BMI）여대조조무명현차이（P＞0．05）；병례조혈청E1이급총연구대상적혈청E1、TSTO、AED재초중조내적수평명현고우비초중조（P＜0．05），미발현기여각조적격소수평여BMI지수구유상관성（P＞0．05）。결론절경후녀성유선암환자적혈청성격소수평승고，혈청E2、E1、AED수평승고가능시여절경후녀성유선암적발병상관，BMI고적절경후녀성적혈청성격소수평교고。
Objective To investigate the association between serum sex hormone levels as well as body mass index and breast cancer in postmenopausal women .Methods We selected the cases of postmenopausal women who accepted surgical treatment for the first time which from March 2013 to December 2013 in the depart-ment of breast surgery the Affiliated Tumor Hospital of Harbin Medical University ,of which 118 cases of patients with breast cancer and 60 cases of benign breast lesions as control group .Meanwhile,information of body height and weight.were collected.Serum estradiol(E2),estrone(E1),testosterone(TSTO)and androstenedione(AED) concentrations were measured in 118 postmenopausal women with breast cancer patients and 60 matched control subjects by enzyme-linked immunosorbent assay(ELISA),then the results were estimated.Results The levels of serum E2,E1,AED of breast cancer group were significantly higher than those in control group (P<0.05). The serum level of TSTO in cases group was higher than the control group ,but the results were not statistically significant(P>0.05).The levels of body mass index(BMI)were not statistically significant(P>0.05)between breast cancer group and the control group .The level of E1 in breast cancer group and levels of E 1,TSTO,AED in overall of overweight group were significantly higher in overweight (P<0.05),yet we have not found association between levels of hormone and BMI .Conclusion The level of serum sex hormones is higher with breast cancer in postmenopausal women ,while high serum levels of E2,E1,AED maybe associated with breast cancer in postm-enopausal women .Sex hormones are higher in postmenopausal women with high BMI .