CAJ | 학술논문

背景：ANK3基因rs10761482多态性已被发现与精神分裂症的发生相关联。 　　目的：评估新疆维吾尔族人群ANK3基因和精神分裂症之间的关联。 　　方法：使用Taqman探针技术对630例新疆维吾尔族精神分裂症患者和535名新疆维吾尔族健康人群进行ANK3基因rs10761482位点的基因分型。采用SHEsis和SPSS17.0软件进行数据分析。 　　结果：病例组和对照组之间的基因型和等位基因频率无显著差异。在病例组，性别或精神分裂症发病年龄与基因型或等位基因频率之间没有显著关联。将男性和女性单独分析，病例组与对照组之间的等位基因和基因型频率均未发现显著差异，青春期发病与成年后 　　发病的精神分裂症患者之间的等位基因和基因型频率也无显著差异。 　　结论：我们的研究结果不支持以往ANK3基因与精神分裂症有关联的报告。本研究招募的维吾尔族人群中， ANK3基因rs10761482多态性与精神分裂症之间没有显著关联。如果这些结果在进一步的研究中得到证实，那么研究重点将转而了解为什么在这个特定的族群中不存在上述已经被广泛认可的关联。
배경：ANK3기인rs10761482다태성이피발현여정신분렬증적발생상관련。 　　목적：평고신강유오이족인군ANK3기인화정신분렬증지간적관련。 　　방법：사용Taqman탐침기술대630례신강유오이족정신분렬증환자화535명신강유오이족건강인군진행ANK3기인rs10761482위점적기인분형。채용SHEsis화SPSS17.0연건진행수거분석。 　　결과：병례조화대조조지간적기인형화등위기인빈솔무현저차이。재병례조，성별혹정신분렬증발병년령여기인형혹등위기인빈솔지간몰유현저관련。장남성화녀성단독분석，병례조여대조조지간적등위기인화기인형빈솔균미발현현저차이，청춘기발병여성년후 　　발병적정신분렬증환자지간적등위기인화기인형빈솔야무현저차이。 　　결론：아문적연구결과불지지이왕ANK3기인여정신분렬증유관련적보고。본연구초모적유오이족인군중， ANK3기인rs10761482다태성여정신분렬증지간몰유현저관련。여과저사결과재진일보적연구중득도증실，나요연구중점장전이료해위십요재저개특정적족군중불존재상술이경피엄범인가적관련。
Background:The rs10761482 polymorphism of the ANK3 gene has been associated with the occurrence of schizophrenia. Aim:Assess the relaitonship between the ANK3 gene and schizophrenia in individuals of Uyghurian descent. Methods:A total of 630 patients with schizophrenia and 535 healthy controls of Uyghur descent were genotyped for the ANK3 gene rs10761482 locus using Taqman probe technology. SHEsis and SPSS17.0 sotfware were used for data analysis. Results:There were no signiifcant differences in the genotype or allele frequencies between the case group and control group. Within the case group there was no relationship between gender or age of onset of schizophrenia and the genotype or allele frequencies. Separate analyses among men and among women also failed to identify significant differences in the allele and genotype frequencies between cases and controls or between paitents with adolescent-onset schizophrenia and those with adult-onset schizophrenia Conclusions:Our ifndings do not support previous reports about the relaitonship of the ANK3 gene and schizophrenia. In the Uyghur naitonality group recruited for this study there was no signiifcant associaiton between the ANK3 gene rs10761482 polymorphism and schizophrenia. If these results are replicated in further studies, then the focus should change to understanding why this widely acknowledged associaiton does not exist in this paritcular ethnic group.