CAJ | 학술논문

恶性肿瘤的生长和转移离不开新生血管的形成。 Slit2－Robo1信号通路最初是在神经系统中被发现，且在轴突导向生长和神经细胞迁移过程中发挥重要作用，血管系统和神经系统的结构和功能具有相似之处，近年来研究发现Slit2－Robo1信号通路在血管系统，特别是肿瘤血管中具有重要的作用，并在不同肿瘤中发挥的作用不同，已发现Slit2－Robo1可以抑制乳腺癌脑转移的扩散，同时，Slit2－Robo1也可以促进黑素瘤中的肿瘤生长。本文对与肺癌相关的Slit2－Robo1信号通路现状做一综述。
악성종류적생장화전이리불개신생혈관적형성。 Slit2－Robo1신호통로최초시재신경계통중피발현，차재축돌도향생장화신경세포천이과정중발휘중요작용，혈관계통화신경계통적결구화공능구유상사지처，근년래연구발현Slit2－Robo1신호통로재혈관계통，특별시종류혈관중구유중요적작용，병재불동종류중발휘적작용불동，이발현Slit2－Robo1가이억제유선암뇌전이적확산，동시，Slit2－Robo1야가이촉진흑소류중적종류생장。본문대여폐암상관적Slit2－Robo1신호통로현상주일종술。
Tumor growth and migration are correlated with continuous neovascularization .Slit2-Robo1 signal pathway initially positioned in the nervous system plays an important role in the growth and neuronal axon guidance during migration.However,vascular system resembles the structural features and growth mechanism of neural system .Recent researches have shown that Slit 2-Robo1 signaling pathway plays an important role in vas-cular system,especially in tumor vessel .And Slit2-Robo1 has been shown to play a role in brain metastasis in breast cancer and supporting tumor growth in melanoma .Therefore,the role of Slit2-Robo1 in tumor growth and migration depends on the cancer type .Currently ,researches in this field show controversial results .And the status of Slit2-Robo1 signaling pathway in lung cancer is reviewed in this essay .