四川精神卫生
四川精神衛生
사천정신위생
SICHUAN MENTAL HEALTH
2014年
5期
452-455
,共4页
度洛西汀%老年抑郁症%Meta分析
度洛西汀%老年抑鬱癥%Meta分析
도락서정%노년억욱증%Meta분석
Senile depression%Duloxetine%Meta-analysis
目的：探讨度洛西汀治疗老年抑郁症的疗效和不良反应的差异。方法应用Meta分析对10篇度洛西汀治疗老年抑郁症对照研究的文章进行再分析,评价其合并效应量大小并进行显著性检验。结果①度洛西汀自身对照比较的治疗效应极大,合并效应量d=4.59,95%CI(3.01,6.17),χ2=21.5,P<0.01；②度洛西汀与氯氮平在第2周末和治疗后组间比较,疗效差异无统计学意义(P>0.05),差异效应偏小,分别为Y合并=-0.04,95%CI(-0.19,0.11),χ2=3.86,P>0.05；Y合并=0.01,95%CI(-0.14,0.17),χ2=3.06,P>0.05；③两组不良反应差异无统计学意义(P>0.05)。结论度洛西汀治疗老年抑郁症疗效好,不良反应少。
目的：探討度洛西汀治療老年抑鬱癥的療效和不良反應的差異。方法應用Meta分析對10篇度洛西汀治療老年抑鬱癥對照研究的文章進行再分析,評價其閤併效應量大小併進行顯著性檢驗。結果①度洛西汀自身對照比較的治療效應極大,閤併效應量d=4.59,95%CI(3.01,6.17),χ2=21.5,P<0.01；②度洛西汀與氯氮平在第2週末和治療後組間比較,療效差異無統計學意義(P>0.05),差異效應偏小,分彆為Y閤併=-0.04,95%CI(-0.19,0.11),χ2=3.86,P>0.05；Y閤併=0.01,95%CI(-0.14,0.17),χ2=3.06,P>0.05；③兩組不良反應差異無統計學意義(P>0.05)。結論度洛西汀治療老年抑鬱癥療效好,不良反應少。
목적：탐토도락서정치료노년억욱증적료효화불량반응적차이。방법응용Meta분석대10편도락서정치료노년억욱증대조연구적문장진행재분석,평개기합병효응량대소병진행현저성검험。결과①도락서정자신대조비교적치료효응겁대,합병효응량d=4.59,95%CI(3.01,6.17),χ2=21.5,P<0.01；②도락서정여록담평재제2주말화치료후조간비교,료효차이무통계학의의(P>0.05),차이효응편소,분별위Y합병=-0.04,95%CI(-0.19,0.11),χ2=3.86,P>0.05；Y합병=0.01,95%CI(-0.14,0.17),χ2=3.06,P>0.05；③량조불량반응차이무통계학의의(P>0.05)。결론도락서정치료노년억욱증료효호,불량반응소。
Objective To study the difference of efficacy and side effect of duloxetine in the treatmrent of senile depression. Methods 10 comparative studies of duloxetine and other antidepressants in the treatment of senile depression were analyzed by meta-analysis. Results ①Self-comparison study of duloxetine before and after treatment showed that d=4. 59,95%CI(3. 01,6. 17),χ2 =21. 5,P<0. 01. Comparison between duloxetine and the controlled antidepressants at 2 weeks treatment and at the end of each tril showed that Yco = -0. 04,95%CI( -0. 19,0. 11),χ2 =3. 86,P>0. 05, and Yco =0. 01,95%CI( -0. 14,0. 17),χ2 =3. 06,P>0. 05 respectiveiy,which revealed that there was no significant difference between duloxetine and the controlled antidepressants with respect to the clinical efficacy. There were no significant difference in side effect between these two groups. Conclusion Duloxetine is an safe and effective antidepressant in the treatment of senile depression.
