CAJ | 학술논문

目的：探讨甲状腺功能与首发精神分裂症之间的相关性及临床意义。方法自编调查表收集2011年4月-2013年8月在芜湖市第四人民医院住院治疗的首发精神分裂症患者84例及门诊健康体检者46例,采用co-bas? e411电化学发光全自动免疫分析仪分别测定两组血清三碘甲状腺原氨酸( T3)、甲状腺素( T4)、游离甲状腺激素(FT3、FT4)和促甲状腺激素(TSH)水平,并应用SPSS 13.0统计软件进行χ2检验及t检验。结果患者组血清T4(100.88±24.10)、FT3(4.64±4.64)低于正常对照组血清T4(108.09±15.13)、FT3(4.97±4.97),差异有统计学意义(P=0.039,P=0.012),血清T3、FT4、TSH与正常对照组比较,差异无统计学意义(P>0.05)；首发精神分裂症女性组血清FT3(4.45±0.82)、FT4(16.40±3.48)与男性组血清FT3(5.07± 1.00)、FT4(18.51±3.37)比较差异有统计学意义(P均<0.05)。结论首发精神分裂症,尤其是女性精神分裂症的发生与甲状腺异常高度相关,应采取有效措施应对。
목적：탐토갑상선공능여수발정신분렬증지간적상관성급림상의의。방법자편조사표수집2011년4월-2013년8월재무호시제사인민의원주원치료적수발정신분렬증환자84례급문진건강체검자46례,채용co-bas? e411전화학발광전자동면역분석의분별측정량조혈청삼전갑상선원안산( T3)、갑상선소( T4)、유리갑상선격소(FT3、FT4)화촉갑상선격소(TSH)수평,병응용SPSS 13.0통계연건진행χ2검험급t검험。결과환자조혈청T4(100.88±24.10)、FT3(4.64±4.64)저우정상대조조혈청T4(108.09±15.13)、FT3(4.97±4.97),차이유통계학의의(P=0.039,P=0.012),혈청T3、FT4、TSH여정상대조조비교,차이무통계학의의(P>0.05)；수발정신분렬증녀성조혈청FT3(4.45±0.82)、FT4(16.40±3.48)여남성조혈청FT3(5.07± 1.00)、FT4(18.51±3.37)비교차이유통계학의의(P균<0.05)。결론수발정신분렬증,우기시녀성정신분렬증적발생여갑상선이상고도상관,응채취유효조시응대。
Objective To explore the relationship between thyroid function and first-episode schizophrenia and clinical signifi-cance. Methods A total of 84 unrelated schizophrenia inpatients were recruited from the Fourth People's Hospital of Wuhu City from December 2008 to August 2010. Self-made questionnaire was applied to collect the demographic data of all subjects. The cobas? e411 automatic electrochemiluminescence immunoassay analyzer was determined respectively to the two groups of serum thyroid glycine (T3),thyroxine(T4),freethyroidhormones(FT3,FT4)andthyroid-stimulatinghormone(TSH)level. AndtheSPSS13.0statis-tical software was carried on the chi-square test and t test. Results The serum T4(100.88 ±24.10) and FT3(4.64 ±4.64)levels in first-episode schizophrenia patients were lower than those in normal controls[(108. 09 ± 15. 13), P=0. 039;(4. 97 ± 4. 97),P=0. 012]. No significant differences were found in serum T3, FT4 and TSH levels between first-episode schizophrenia patients and con-trols(P>0. 05). The serum FT3 (4. 45 ± 0. 82) and FT4 (16. 40 ± 3. 48) levels in the female first-episode schizophrenia patients were significantly lower than that in the male group[(5. 07 ± 1. 00),P<0. 05;(18. 51 ± 3. 37),P<0. 05]. Conclusion First-epi-sode schizophrenia, especially female, the incidence of that are highly correlated with thyroid abnormalities , and effective measures should be taken to deal with.