CAJ | 학술논문

去甲斑蝥素是临床常用抗肝癌药物，抗肿瘤作用强，并且具有保护肝细胞、提高免疫功能等作用。为提高其对肝脏的靶向性，降低对其他脏器的毒性，近年来不断有学者进行去甲斑蝥素主动肝靶向性药物的设计，如单克隆抗体导向药物、去唾液酸糖蛋白介导的药物等。本文综述了近十年来对去甲斑蝥素主动肝靶向性药物的研究进展，为开发应用于临床的去甲斑蝥素主动肝靶向性药物的研究提供参考。
거갑반모소시림상상용항간암약물，항종류작용강，병차구유보호간세포、제고면역공능등작용。위제고기대간장적파향성，강저대기타장기적독성，근년래불단유학자진행거갑반모소주동간파향성약물적설계，여단극륭항체도향약물、거타액산당단백개도적약물등。본문종술료근십년래대거갑반모소주동간파향성약물적연구진전，위개발응용우림상적거갑반모소주동간파향성약물적연구제공삼고。
Norcantharidin is a commonly used anti-liver cancer drug with high anti-tumor activity in clinical practice. It can protect liver cells and improve immune functions as well. In recent years, research-ers have been focusing on designing active liver-targeting drugs of norcantharidin, such as monoclonal anti-body-directed drug or asialoglycoprotein receptor-mediated drug, to improve its specificity to liver as well as to reduce its toxicity to other tissues and organs. This paper reviews the research progress on active liver-tar-geting drugs of norcantharidin derivertives in recent ten years. All of these researches aim to will provide ref-erences to further study and exploitation on clinically available norcantharidin active liver-targeting drugs.