CAJ | 학술논문

目的：探讨碧血胶囊对大鼠急性心肌梗死的保护作用。方法采用麻醉开胸结扎冠状动脉左前降支造成急性心肌梗死模型，将60只雄性SD大鼠随机分为：假手术组、急性心肌梗死模型组、通心络组、碧血胶囊高、低剂量组、地尔硫卓组。测定用药前后大鼠模型心电图、心律失常、心梗面积以及血清肌酸激酶、乳酸脱氢酶、丙二醛、超氧化物歧化酶的变化。结果与急性心肌梗死模型组比较，碧血胶囊高剂量组能够明显减少冠脉结扎大鼠的心肌梗死面积( P<0．05)及血中丙二醛、肌酸激酶的含量(P<0．05)，显著降低急性心肌缺血所致T波的高抬(P<0．01)。结论碧血胶囊能减轻大鼠心肌梗死时的心肌缺血程度及心律失常的发生率，降低心肌梗死面积及血清肌酸激酶和丙二醛的水平，对大鼠急性心肌梗死具有一定的保护作用。
목적：탐토벽혈효낭대대서급성심기경사적보호작용。방법채용마취개흉결찰관상동맥좌전강지조성급성심기경사모형，장60지웅성SD대서수궤분위：가수술조、급성심기경사모형조、통심락조、벽혈효낭고、저제량조、지이류탁조。측정용약전후대서모형심전도、심률실상、심경면적이급혈청기산격매、유산탈경매、병이철、초양화물기화매적변화。결과여급성심기경사모형조비교，벽혈효낭고제량조능구명현감소관맥결찰대서적심기경사면적( P<0．05)급혈중병이철、기산격매적함량(P<0．05)，현저강저급성심기결혈소치T파적고태(P<0．01)。결론벽혈효낭능감경대서심기경사시적심기결혈정도급심률실상적발생솔，강저심기경사면적급혈청기산격매화병이철적수평，대대서급성심기경사구유일정적보호작용。
Objective To investigate the protective effects of Bixue capsule on acute myocardial infarction ischemia rats. Methods Acute Myocardial Infarction ( AMI) model was induced by left coro-nary artery ligation. Sixty healthy Spraugue-Dawley male rats were randomly divided into sham operated group, MI group, high and low dose Bixue capsule groups, Diltiazem groups and Tongxinluo capsule con-trol groups. The changes of T waveform, MI area and serum SOD, MDA, LDH, CK levels were measured after ligation. Results compared to MI group, high dose Bixue capsule group can reduce the increased MI area (P<0. 05), serum CK and MDA levels (P<0. 05) and T waveform (P<0. 01) caused by acute myocardial ischemia. Conclusion Pretreatment with Bixue capsule effectively improved the ischemic myo-cardial through reducing T waveform, myocardial infarction area and serum CK and MDA levels.