CAJ | 학술논문

目的：分析血T-SPOT． TB联合肺泡灌洗液( BALF) TbDNA检测对肺结核诊断的价值。方法选择2013．3~11月86例疑似肺结核患者，经确诊后分为肺结核组46例、肺炎组40例，均行 T-SPOT． TB、BALF-TbDNA、BALF涂片、痰涂片、PPD、结核抗体检测，对各检测结果进行对比，并行 T-SPOT． TB与 BALF-TbDNA联合检测与单用检测、涂片法、PPD、结核抗体对比分析。结果血T-SPOT． TB、BALF-TbDNA敏感性分别为84．8%、80．4%，特异性分别为80．0%、77．5%，两者联合检测敏感性为100．0%，阳性预测值为97．1%，阴性预测值为100．0%，与单用检测对比，差异有统计学意义( P<0．05)，与涂片法、PPD、结核抗体对比，存在显著差异(P<0．01)。结论血T-SPOT． TB与BALF-TbDNA联合检测提高了肺结核的诊断阳性率，弥补对方不足，减少肺结核的漏诊、误诊，是一个有前途的检测方法。
목적：분석혈T-SPOT． TB연합폐포관세액( BALF) TbDNA검측대폐결핵진단적개치。방법선택2013．3~11월86례의사폐결핵환자，경학진후분위폐결핵조46례、폐염조40례，균행 T-SPOT． TB、BALF-TbDNA、BALF도편、담도편、PPD、결핵항체검측，대각검측결과진행대비，병행 T-SPOT． TB여 BALF-TbDNA연합검측여단용검측、도편법、PPD、결핵항체대비분석。결과혈T-SPOT． TB、BALF-TbDNA민감성분별위84．8%、80．4%，특이성분별위80．0%、77．5%，량자연합검측민감성위100．0%，양성예측치위97．1%，음성예측치위100．0%，여단용검측대비，차이유통계학의의( P<0．05)，여도편법、PPD、결핵항체대비，존재현저차이(P<0．01)。결론혈T-SPOT． TB여BALF-TbDNA연합검측제고료폐결핵적진단양성솔，미보대방불족，감소폐결핵적루진、오진，시일개유전도적검측방법。
Objective To analyze the value of pulmonary tuberculosis diagnosis by detecting blood T-SPOT. TB combined with bronchoalveolar lavage fluid ( BALF) TbDNA. Methods 86 suspected pulmonary tubercu-losis patients were confirmed and then divided into two groups. The group A had 46 cases of pulmonary tuberculosis, and the group B had 40 cases of pneumonia. The two groups were given blood T-SPOT. TB, BALF-TbDNA, BALF smear, sputum smear, PPD and tuberculosis antibody. Results The sensitivity of blood T-SPOT. TB and BALF-TbDNA was respectively 84. 8% and 80. 4%, and the specificity was respectively 80. 0% and 77. 5%. The sensitivity, positive predictive value, and negative predictive value of blood T-SPOT. TB combined with BALF TbDNA test was respectively 100%, 97. 1%, and 100% ( P<0. 05 ) . Conclusion The detection of blood T-SPOT. TB combined with BALF TbDNA can improve the positive rate of tuberculosis diagnosis.