临床肺科杂志
臨床肺科雜誌
림상폐과잡지
JOUNAL OF CLINICAL PULMONARY MEDICINE
2014年
12期
2189-2191
,共3页
慢性阻塞性肺疾病%IL-23%IL-17%IL-10%BODE指数
慢性阻塞性肺疾病%IL-23%IL-17%IL-10%BODE指數
만성조새성폐질병%IL-23%IL-17%IL-10%BODE지수
chronic obstructive pulmonary disease%IL-23%IL-17%IL-10%BODE index
目的：探讨慢性阻塞性肺疾病稳定期患者痰中IL-23、IL-17及IL-10变化及其与BODE指数的关系。方法所有志愿者接受体重、身高、肺功能、呼吸困难程度、6分钟步行实验测量以 BODE 评分,用ELASA法检测36名慢性阻塞性肺疾病稳定期患者及22名健康对照组诱导痰中IL-23、IL-17及IL-10。结果与健康对照组相比,COPD稳定期患者IL-23、IL-17升高(P<0．05), IL-10降低(P<0．05)；COPD稳定期患者痰中IL-23、IL-17与BODE指数正相关,IL-10与BODE指数负相关( rs 分别为0．670、0．609、-0．526,P<0．05)。结论 IL-17、IL-23、IL-10可能参与COPD的发病,且IL-17、IL-23与病情的严重程度正相关,IL-10与病情的严重程度负相关。检测IL-17、IL-23、IL-10水平有助于评估COPD的疾病严重程度。
目的：探討慢性阻塞性肺疾病穩定期患者痰中IL-23、IL-17及IL-10變化及其與BODE指數的關繫。方法所有誌願者接受體重、身高、肺功能、呼吸睏難程度、6分鐘步行實驗測量以 BODE 評分,用ELASA法檢測36名慢性阻塞性肺疾病穩定期患者及22名健康對照組誘導痰中IL-23、IL-17及IL-10。結果與健康對照組相比,COPD穩定期患者IL-23、IL-17升高(P<0．05), IL-10降低(P<0．05)；COPD穩定期患者痰中IL-23、IL-17與BODE指數正相關,IL-10與BODE指數負相關( rs 分彆為0．670、0．609、-0．526,P<0．05)。結論 IL-17、IL-23、IL-10可能參與COPD的髮病,且IL-17、IL-23與病情的嚴重程度正相關,IL-10與病情的嚴重程度負相關。檢測IL-17、IL-23、IL-10水平有助于評估COPD的疾病嚴重程度。
목적：탐토만성조새성폐질병은정기환자담중IL-23、IL-17급IL-10변화급기여BODE지수적관계。방법소유지원자접수체중、신고、폐공능、호흡곤난정도、6분종보행실험측량이 BODE 평분,용ELASA법검측36명만성조새성폐질병은정기환자급22명건강대조조유도담중IL-23、IL-17급IL-10。결과여건강대조조상비,COPD은정기환자IL-23、IL-17승고(P<0．05), IL-10강저(P<0．05)；COPD은정기환자담중IL-23、IL-17여BODE지수정상관,IL-10여BODE지수부상관( rs 분별위0．670、0．609、-0．526,P<0．05)。결론 IL-17、IL-23、IL-10가능삼여COPD적발병,차IL-17、IL-23여병정적엄중정도정상관,IL-10여병정적엄중정도부상관。검측IL-17、IL-23、IL-10수평유조우평고COPD적질병엄중정도。
Objective To explore the correlation of the changes of IL-17, IL-23 and IL-10 to the indexes of COPD and BODE. Methods All volunteers ’ height, weight, lung function, modified medical research council ( MMRC) and six-minute walking distance were collected for estimating BODE index. Induced sputum samples were collected from 36 patients with COPD and 22 healthy people. The levels of IL-23, IL-17and IL-10 were measured by ELISA. Results The levels of IL-23 and IL-17 increased more significantly, and the level of IL-10 decreased more obviously in COPD patients than in the healthy controls ( P<0. 05 ) . The levels of IL-23 and IL-17 were positively related with the indexes of BODE, and the level of IL-10 was negatively related with the indexes of BODE in COPD patients at stable stage. Conclusion IL-17,IL-23 and IL-10 may play important roles in the pathogenesis of COPD. The detection of IL-17, IL-23 and IL-10 can help to evaluate the severity of COPD.
