CAJ | 학술논문

目的：研究观察多索茶碱对慢性阻塞性肺疾病患者气道重塑与痰液、血清炎性指标的影响。方法选取2011年10月~2013年8月本院收治的80例慢性阻塞性肺疾病患者为研究对象，将其随机分为对照组(氨茶碱治疗组)40例和观察组(多索茶碱治疗组)40例，两组患者治疗前与治疗后5 d、10 d的血清气道重塑指标及痰液、血清炎性指标进行检测与比较。结果观察组治疗后5 d、10 d的血清气道重塑指标及痰液、血清炎性指标均显著地低于对照组，并且观察组治疗后5 d、10 d的检测水平均明显地低于本组治疗前(P均<0．05)，均有显著性差异。结论多索茶碱可有效改善慢性阻塞性肺疾病患者气道重塑状态，并对控制痰液、血清炎性指标发挥着积极的临床作用。
목적：연구관찰다색다감대만성조새성폐질병환자기도중소여담액、혈청염성지표적영향。방법선취2011년10월~2013년8월본원수치적80례만성조새성폐질병환자위연구대상，장기수궤분위대조조(안다감치료조)40례화관찰조(다색다감치료조)40례，량조환자치료전여치료후5 d、10 d적혈청기도중소지표급담액、혈청염성지표진행검측여비교。결과관찰조치료후5 d、10 d적혈청기도중소지표급담액、혈청염성지표균현저지저우대조조，병차관찰조치료후5 d、10 d적검측수평균명현지저우본조치료전(P균<0．05)，균유현저성차이。결론다색다감가유효개선만성조새성폐질병환자기도중소상태，병대공제담액、혈청염성지표발휘착적겁적림상작용。
Objective To study and observe the influence of doxofylline on the airway remodeling and spu-tum and serum inflammatory indexes of patients with chronic obstructive pulmonary disease. Methods 80 patients with chronic obstructive pulmonary in our hospital from October 2011 to August 2013 were randomly divided into the control group (the aminophylline treatment group) and the observation group (the doxofylline group), 40 cases in each group. The serum airway remodeling and the inflammatory indexes sputum and serum in the two groups were de-tected and compared before and 5 and 10 days after the treatment. Results 5 and 10 days after the treatment, the indexes of serum airway remodeling and sputum and serum inflammatory decreased significantly in the two groups, and the decrease was more pronounced in the observation group than in the control group (P<0. 05). Conclusion Doxofylline can effectively improve the airway remodeling state and have active clinical effect in controlling the sputum and serum inflammatory indexes of patients with chronic obstructive pulmonary.