临床肺科杂志
臨床肺科雜誌
림상폐과잡지
JOUNAL OF CLINICAL PULMONARY MEDICINE
2014年
12期
2171-2173
,共3页
固尔苏%肺表面活性物质%鼻塞式持续气道正压通气%新生儿呼吸窘迫综合征
固爾囌%肺錶麵活性物質%鼻塞式持續氣道正壓通氣%新生兒呼吸窘迫綜閤徵
고이소%폐표면활성물질%비새식지속기도정압통기%신생인호흡군박종합정
curosurf%pulmonary surfactant%nasal continuous positive airway pressure%neonatal respiratory distress syndrome
目的：探讨固尔苏联合鼻塞式持续气道正压通气( NCPAP )治疗新生儿呼吸窘迫综合征( NRDS)的临床疗效。方法72例NRDS患儿按数字表随机分为两组，对照组( n=36例)在综合治疗措施上采用沐舒坦联合NCPAP治疗，观察组( n=36例)在综合治疗措施上采用固尔苏联合NCPAP治疗。观察两组患儿临床疗效，治疗前后临床表现，比较两组患儿治疗后1、12、24h NCPAP参数( FiO2、PIP、PEEP、Flow)、动脉血气指标(pH、PaO2、PaCO2、PaO2/FiO2)的变化。结果观察组治疗总有效率(88．9%)明显高于对照组治疗总有效率(72．2%)(P<0．05)；随着治疗时间延长，两组患儿动脉血气指标和NCPAP参数均得到改善，且观察组动脉血气指标和NCPAP参数(FiO2、PIP)改善较对照组更为显著(P<0．05)。结论固尔苏联合NCPAP治疗NRDS患儿疗效显著，可明显改善动脉血气指标和NCPAP参数，值得临床推广应用。
目的：探討固爾囌聯閤鼻塞式持續氣道正壓通氣( NCPAP )治療新生兒呼吸窘迫綜閤徵( NRDS)的臨床療效。方法72例NRDS患兒按數字錶隨機分為兩組，對照組( n=36例)在綜閤治療措施上採用沐舒坦聯閤NCPAP治療，觀察組( n=36例)在綜閤治療措施上採用固爾囌聯閤NCPAP治療。觀察兩組患兒臨床療效，治療前後臨床錶現，比較兩組患兒治療後1、12、24h NCPAP參數( FiO2、PIP、PEEP、Flow)、動脈血氣指標(pH、PaO2、PaCO2、PaO2/FiO2)的變化。結果觀察組治療總有效率(88．9%)明顯高于對照組治療總有效率(72．2%)(P<0．05)；隨著治療時間延長，兩組患兒動脈血氣指標和NCPAP參數均得到改善，且觀察組動脈血氣指標和NCPAP參數(FiO2、PIP)改善較對照組更為顯著(P<0．05)。結論固爾囌聯閤NCPAP治療NRDS患兒療效顯著，可明顯改善動脈血氣指標和NCPAP參數，值得臨床推廣應用。
목적：탐토고이소연합비새식지속기도정압통기( NCPAP )치료신생인호흡군박종합정( NRDS)적림상료효。방법72례NRDS환인안수자표수궤분위량조，대조조( n=36례)재종합치료조시상채용목서탄연합NCPAP치료，관찰조( n=36례)재종합치료조시상채용고이소연합NCPAP치료。관찰량조환인림상료효，치료전후림상표현，비교량조환인치료후1、12、24h NCPAP삼수( FiO2、PIP、PEEP、Flow)、동맥혈기지표(pH、PaO2、PaCO2、PaO2/FiO2)적변화。결과관찰조치료총유효솔(88．9%)명현고우대조조치료총유효솔(72．2%)(P<0．05)；수착치료시간연장，량조환인동맥혈기지표화NCPAP삼수균득도개선，차관찰조동맥혈기지표화NCPAP삼수(FiO2、PIP)개선교대조조경위현저(P<0．05)。결론고이소연합NCPAP치료NRDS환인료효현저，가명현개선동맥혈기지표화NCPAP삼수，치득림상추엄응용。
Objective To study the curative effect of curosurf combined with nasal continuous positive air-way pressure ( NCPAP) in the treatment of neonatal respiratory distress syndrome ( NRDS) . Methods 72 children with NRDS were randomly divided into two groups. The control group (n=36) was treated with mucosolvan com-bined with NCPAP on comprehensive treatment measures, and the observation group (n=36) was treated with curo-surf combined with NCPAP on comprehensive treatment measures. The clinical curative effect, clinical symptoms be-fore and after the treatment of the two groups were observed, and the changes of NCPAP parameters ( FiO2、PIP、PEEP、Flow), arterial blood gas index (pH、PaO2、PaCO2、PaO2/FiO2) in the two groups 1, 12, 24h after the treat-ment were compared. Results The total effective rate of the observation group ( 88. 9%) was significantly higher than that of the control group(72. 2%) (P<0. 05). With treatment prolonged, the arterial blood gas index and NC-PAP parameters of the two groups were improved, and the improvement was more pronounced in the observation group than in the control group (P<0. 05). Conclusion Curosurf combined with NCPAP has a good curative effect in the treatment of NRDS, which can significantly improve the arterial blood gas index and NCPAP parameters.
