CAJ | 학술논문

先导化合物是现代新药研发的出发点，发现和寻找先导化合物有多种多样的途径和方法。虚拟化合物是一种基于受体结构的三维信息，采用计算机辅助药物设计技术设计出的能与受体特异性结合的先导化合物。是否保护专利化合物的虚拟形式使用和由此产生的虚拟化合物是决定这一全新药物设计方法广泛普及和向前发展的关键所在。
선도화합물시현대신약연발적출발점，발현화심조선도화합물유다충다양적도경화방법。허의화합물시일충기우수체결구적삼유신식，채용계산궤보조약물설계기술설계출적능여수체특이성결합적선도화합물。시부보호전리화합물적허의형식사용화유차산생적허의화합물시결정저일전신약물설계방법엄범보급화향전발전적관건소재。
The lead compound is the starting point of the development of modern medicine.There are a lot of methods in discovering and distinguishing the lead compounds.Virtual compound,based on three -dimensional receptor structural in-formation and employs computer aided drug design methods,generates and optimizes the lead compound.Whether or not to protect of the virtual form use of a chemical compound and virtual compound is the key factor to popularize and develop the De Novo design.