CAJ | 학술논문

脂质体（liposome，LP）是一种人工制备的球形磷脂双分子层囊泡，由于生物体质膜的基本结构也是磷脂双分子层膜，脂质体具有与生物体细胞相似的结构，因此有较好的生物相容性，同时也具有生物可降解性、免疫原性小及无明显毒性等优势。脂质体作为药物的有效载体已经得到广泛应用，近年来其封装荧光染料进行肿瘤方面的示踪研究也有所报道。随着表面修饰材料及制备方法的不断发展，脂质体作为一种运输载体将更具明显优势，目前研究热衷以长循环和靶向脂质体封装药物和荧光染料的研究。本文将主要讨论长循环和靶向脂质体在肿瘤研究的应用和进展。
지질체（liposome，LP）시일충인공제비적구형린지쌍분자층낭포，유우생물체질막적기본결구야시린지쌍분자층막，지질체구유여생물체세포상사적결구，인차유교호적생물상용성，동시야구유생물가강해성、면역원성소급무명현독성등우세。지질체작위약물적유효재체이경득도엄범응용，근년래기봉장형광염료진행종류방면적시종연구야유소보도。수착표면수식재료급제비방법적불단발전，지질체작위일충운수재체장경구명현우세，목전연구열충이장순배화파향지질체봉장약물화형광염료적연구。본문장주요토론장순배화파향지질체재종류연구적응용화진전。
Liposome is an artificially prepared spherical vesicle that has a phospholipid bilayer. Given that the basic structure of its biological membrane is also a lipid bilayer membrane, liposome shares similar structures with body cells Therefore, liposome has good biocompatibility and advantages such as biodegradability, low immunogenicity, and subtle toxicity. Liposome has been widely ap-plied as an effective drug carrier. Studies on liposome-encapsulated fluorescent dye on tumor tracing have been reported in recent years. Liposome can become a more advantageous transport carrier with continuous development of surface modification materials and prepa-ration methods. The long cycle, targeted liposome-encapsulated drugs, and fluorescent dye have become the focus of interest for several researchers. This article mainly discusses the application and progress of long cycle and targeted liposome in cancer research.