中国肿瘤临床
中國腫瘤臨床
중국종류림상
CHINESE JOURNAL OF CLINICAL ONCOLOGY
2014年
21期
1374-1378
,共5页
山长平%夏重升%杨娅%王军业%苏修军
山長平%夏重升%楊婭%王軍業%囌脩軍
산장평%하중승%양아%왕군업%소수군
非小细胞肺癌%血小板与淋巴细胞比值%预后
非小細胞肺癌%血小闆與淋巴細胞比值%預後
비소세포폐암%혈소판여림파세포비치%예후
non-small cell lung cancer%platelet-to-lymphocyte ratio%prognosis
目的：探讨术前外周血血小板与淋巴细胞比值（PLR）与非小细胞肺癌患者临床病理特征的相关性及其对患者预后的影响。方法：回顾性分析2004年1月至2007年12月在济宁医学院附属医院行根治性手术切除并经病理诊断明确的255例非小细胞肺癌患者的临床病理资料。以PLR中位数将患者分为低PLR组和高PLR组，分析PLR与患者临床病理因素的相关性，单因素及多因素生存分析评价PLR对患者术后生存的影响。结果：全组患者术前PLR为45.45～272.66，中位值为130。低PLR组（≤130）127例，高PLR组（>130）128例，PLR与肿瘤部位、T分期及临床分期相关（均P<0.05）。低PLR组和高PLR组患者的5年生存率分别为49.6%和33.6%，差异有统计学意义（P<0.001）；单因素分析结果显示：吸烟史、分化程度、临床分期、T分期、N分期、术后辅助治疗及PLR是患者预后的影响因素（均P<0.05），多因素分析表明，N分期、术后辅助治疗及PLR是影响患者预后的独立危险因素（均P<0.05）。分层分析显示，在无淋巴结转移及有淋巴结转移的患者中，低PLR与高PLR组患者的5年生存率差异均有统计学意义（P=0.020及0.037）。结论：术前PLR升高提示患者预后不良，是影响非小细胞肺癌患者预后的独立危险因素。
目的：探討術前外週血血小闆與淋巴細胞比值（PLR）與非小細胞肺癌患者臨床病理特徵的相關性及其對患者預後的影響。方法：迴顧性分析2004年1月至2007年12月在濟寧醫學院附屬醫院行根治性手術切除併經病理診斷明確的255例非小細胞肺癌患者的臨床病理資料。以PLR中位數將患者分為低PLR組和高PLR組，分析PLR與患者臨床病理因素的相關性，單因素及多因素生存分析評價PLR對患者術後生存的影響。結果：全組患者術前PLR為45.45～272.66，中位值為130。低PLR組（≤130）127例，高PLR組（>130）128例，PLR與腫瘤部位、T分期及臨床分期相關（均P<0.05）。低PLR組和高PLR組患者的5年生存率分彆為49.6%和33.6%，差異有統計學意義（P<0.001）；單因素分析結果顯示：吸煙史、分化程度、臨床分期、T分期、N分期、術後輔助治療及PLR是患者預後的影響因素（均P<0.05），多因素分析錶明，N分期、術後輔助治療及PLR是影響患者預後的獨立危險因素（均P<0.05）。分層分析顯示，在無淋巴結轉移及有淋巴結轉移的患者中，低PLR與高PLR組患者的5年生存率差異均有統計學意義（P=0.020及0.037）。結論：術前PLR升高提示患者預後不良，是影響非小細胞肺癌患者預後的獨立危險因素。
목적：탐토술전외주혈혈소판여림파세포비치（PLR）여비소세포폐암환자림상병리특정적상관성급기대환자예후적영향。방법：회고성분석2004년1월지2007년12월재제저의학원부속의원행근치성수술절제병경병리진단명학적255례비소세포폐암환자적림상병리자료。이PLR중위수장환자분위저PLR조화고PLR조，분석PLR여환자림상병리인소적상관성，단인소급다인소생존분석평개PLR대환자술후생존적영향。결과：전조환자술전PLR위45.45～272.66，중위치위130。저PLR조（≤130）127례，고PLR조（>130）128례，PLR여종류부위、T분기급림상분기상관（균P<0.05）。저PLR조화고PLR조환자적5년생존솔분별위49.6%화33.6%，차이유통계학의의（P<0.001）；단인소분석결과현시：흡연사、분화정도、림상분기、T분기、N분기、술후보조치료급PLR시환자예후적영향인소（균P<0.05），다인소분석표명，N분기、술후보조치료급PLR시영향환자예후적독립위험인소（균P<0.05）。분층분석현시，재무림파결전이급유림파결전이적환자중，저PLR여고PLR조환자적5년생존솔차이균유통계학의의（P=0.020급0.037）。결론：술전PLR승고제시환자예후불량，시영향비소세포폐암환자예후적독립위험인소。
Objective:To investigate the correlation between preoperative blood platelet-to-lymphocyte ratio (PLR) and clinico-pathological features, as well as the effect of PLR on the prognosis of non-small cell lung cancer (NSCLC) patients after surgical resec-tion. Methods:Retrospective analysis was performed for 255 cases with histologically confirmed NSCLC that underwent curative re-section from January 2004 to December 2007. All patients were classified into two groups based on the median value of PLR. The rela-tionship between PLR and clinicopathological features was studied. Univariate and multivariate analyses were performed to assess the prognostic effect of preoperative PLR. Results:The median value of preoperative PLR was 130 (range:45.45 to 272.66). Based on the cut-off value of 130, all patients were divided into two groups:low PLR (≤130, n=127) and high PLR (>130, n=128). PLR was corre-lated with tumor site, T stage, and clinical stage. Five-year survival rates of low and high PLR patients were 49.6%and 33.6%, respec-tively, which indicated a statistically significant difference (χ2=12.577, P<0.001) between the two groups. Univariate analysis showed that smoking status, histological differentiation, clinical stage, T stage, N stage, postoperative adjuvant therapy and PLR were associat-ed with survival (P<0.05 for all). Multivariate analysis identified N stage, postoperative adjuvant therapy, and PLR as independent prog-nostic factors of all the patients. In addition, stratified analysis showed that the five-year survival rate of the low PLR group was higher than that of the high PLR group with or without lymph node metastasis, and the differences were statistically significant (P=0.020 and 0.037). Conclusion:An elevated blood preoperative PLR indicates poor prognosis in NSCLC patients. Preoperative PLR is an indepen-dent prognostic factor of NSCLC after curative resection.
