CAJ | 학술논문

目的：探讨胃肠道间质瘤(GIST)伊马替尼辅助治疗的临床疗效。方法收集青岛市市立医院及川北医学院附属医院2007年1月至2012年12月间共67例手术切除的胃肠道间质瘤患者临床及随访资料进行回顾性分析。结果39例局限性患者在随访期间未发生确切转移性病灶；28例转移患者中，伊马替尼治疗2~3个月后临床及影像学评价：部分缓解6例，稳定14例，病情进展8例，其中3例患者对伊马替尼耐药，治疗期间病情持续进展，追加剂量后病情仍未控制，后患者放弃治疗，3~6个月后患者死亡。另5例患者在开始治疗6~12个月内病情稳定，后出现病情进展，在追加剂量后未能控制病情，患者行姑息性手术部分切除进展病灶后继续行伊马替尼治疗，患者病情稳定。结论胃肠道间质瘤伊马替尼辅助治疗能改善患者的愈后，长期使用伊马替尼的患者肿瘤复发率较低，且多数不良反应患者可以耐受。对于高风险的GIST患者推荐手术结合伊马替尼长期维持治疗。
목적：탐토위장도간질류(GIST)이마체니보조치료적림상료효。방법수집청도시시립의원급천북의학원부속의원2007년1월지2012년12월간공67례수술절제적위장도간질류환자림상급수방자료진행회고성분석。결과39례국한성환자재수방기간미발생학절전이성병조；28례전이환자중，이마체니치료2~3개월후림상급영상학평개：부분완해6례，은정14례，병정진전8례，기중3례환자대이마체니내약，치료기간병정지속진전，추가제량후병정잉미공제，후환자방기치료，3~6개월후환자사망。령5례환자재개시치료6~12개월내병정은정，후출현병정진전，재추가제량후미능공제병정，환자행고식성수술부분절제진전병조후계속행이마체니치료，환자병정은정。결론위장도간질류이마체니보조치료능개선환자적유후，장기사용이마체니적환자종류복발솔교저，차다수불량반응환자가이내수。대우고풍험적GIST환자추천수술결합이마체니장기유지치료。
Objective To investigate the GIST adjuvant imatinib clinical efifcacy. Methods Collected the patients treated in our hospital during January 2007 to December 2012. Among 67 cases of surgical resection of GIST patients and follow-up clinical data were retrospectively analyzed. Results 39 cases of limitations showed no sign metastatic lesions;28 cases of multiple metastases patients, 2-3 months after the therapy clinical and radiographic evaluation:some remission in 6 cases, stable in 14 cases, 8 cases of disease progression , including 3 case of imatinib-resistant patients, the disease continued to progress during treatment, an additional dose did not controlled the disease, the patients dead 3-6 months later. The other ifve patients starting treatment within 6-12 months in stable condition, then the dose failed to control the disease, patients underwent palliative surgery after partial resection of lesions and continued the therapy, no obvious signs of metastasis. Conclusion Imatinib adjuvant therapy can improve the prognosis of patients with GIST;long-term use of imatinib can lower the recurrence, and most patients can tolerate adverse reactions. For high-risk GIST patients, recommended palliative surgery and long-term maintenance therapy.