CAJ | 학술논문

Notch信号通路是一条进化过程中高度保守的信号通路，广泛存在于生物进化过程中，是决定细胞命运的重要通路之一，相邻细胞通过Notch受体与配体相互作用转导细胞信号，在细胞的增值、分化及凋亡过程中发挥重要的调控作用。Notch信号通路的异常激活与乳腺癌的发生、发展有着密切关系，本文对Notch信号通路及其异常表达与乳腺癌的关系进行综述，重点讲述Notch信号通路与乳腺癌的发病机制，希望能给靶向治疗乳腺癌带来一条新的思路。
Notch신호통로시일조진화과정중고도보수적신호통로，엄범존재우생물진화과정중，시결정세포명운적중요통로지일，상린세포통과Notch수체여배체상호작용전도세포신호，재세포적증치、분화급조망과정중발휘중요적조공작용。Notch신호통로적이상격활여유선암적발생、발전유착밀절관계，본문대Notch신호통로급기이상표체여유선암적관계진행종술，중점강술Notch신호통로여유선암적발병궤제，희망능급파향치료유선암대래일조신적사로。
During?evolution?signal?patchway,?Notch?signal?patchway?is?a?highiy?conserved?which?is?widely?exist?in?organism?evolution?and?is?one?of?the?important?determine?cells?fate?pathway.?Between?Notch?receptor?and?ligand?interaction?transmit?adjacent?cell?signal,?which?plays?an?important?role?in?regulating?value,?differentiation?and?apoptosis?of?cells.?Notch?signal?pathway?abnormal?activation,?relationship?with?of?breast?cancer.?This?review?Notch?signal?pathway?and?abnormal?express?with?breast?cancer.?This?important?report?Notch?signaling?pathway?in?the?pathogenesis?of?breast?cancer.?I?wish?bring?a?new?strategy?to?provide?breast?cancer?targeted??treatment.