CAJ | 학술논문

目的：观察三氧化二砷治疗中晚期原发性肝癌的近期疗效及不良反应。方法对33例采用单药三氧化二砷10mg/d加入生理盐水静脉滴注连续14d为1个周期，间歇2周，至少使用2个周期。结果全组4例PR，22例NC，7例PD，客观有效率12%。临床受益率：78.8%；疼痛缓解率为82.7%，81.8%患者生存质量提高；该治疗方案不良反应主要表现为Ⅰ～Ⅱ度胃肠道反应和血液学毒性，轻度的肝功能损害。结论三氧化二砷治疗中晚期原发性肝癌有较好疗效，不良反应较小，是肝癌治疗用药的较佳选择，值得临床推广。
목적：관찰삼양화이신치료중만기원발성간암적근기료효급불량반응。방법대33례채용단약삼양화이신10mg/d가입생리염수정맥적주련속14d위1개주기，간헐2주，지소사용2개주기。결과전조4례PR，22례NC，7례PD，객관유효솔12%。림상수익솔：78.8%；동통완해솔위82.7%，81.8%환자생존질량제고；해치료방안불량반응주요표현위Ⅰ～Ⅱ도위장도반응화혈액학독성，경도적간공능손해。결론삼양화이신치료중만기원발성간암유교호료효，불량반응교소，시간암치료용약적교가선택，치득림상추엄。
Objective?To study the clinical therapeutic effects and the side effects of arsenic trioxide(As2O3)when used to treat middle or advanced primary hepatocellular?carcinoma?by?interventional?ways.?Methods?33?cases?with?single?agent?arsenic?trioxide?10?mg/d?and?saline?infusion?for?14?d?for?1?cycles,?2?weeks?intermittent,?at?least?2?cycles.?Results?All the 4 patients with PR, 22 cases of NC, 7 cases of PD, the efifciency of 12%. Clinical beneift rate:78.8%;pain?relief?rate?was?82.7%,?the?quality?of?life?of?patients?with?81.8%?increase;?adverse?reaction?of?the?treatment?mainly?Ⅰ?to?Ⅱ?gastrointestinal?reaction?and?hematologic?toxicity,?liver?function?impairment?mild.?Conclusion?Arsenic?trioxide?in?the?treatment?of?middle?or?advanced?primary?hepatocellular?carcinoma?have?the?good?curative?effect,?less?adverse?reaction,?is?a?good?choice?for?l?hepatocellular?carcinoma?treatment,?worthy?of?clinical?application.