中国医药指南
中國醫藥指南
중국의약지남
CHINA MEDICINE GUIDE
2014年
30期
5-6
,共2页
妊娠期糖尿病%同型半胱氨酸%胱抑素C%胰岛功能
妊娠期糖尿病%同型半胱氨痠%胱抑素C%胰島功能
임신기당뇨병%동형반광안산%광억소C%이도공능
Gestational diabetes mellitus%Homocysteine%Cystatin C%Islet function
目的：探讨妊娠糖尿病（GDM）患者血清同型半胱氨酸（Hcy）、胱抑素C（CysC）水平的变化及其与胰岛功能的关系。方法选择2012年1月至2012年12月门诊确诊的240例GDM患者作为观察组，100例同期健康孕妇作为对照组。通过对血Hcy、CysC、空腹血糖（FBG）、空腹胰岛素（FINS）的测定，比较两组患者血Hcy、CysC、FBG、FINS、HOMA-IR、HOMA-β水平，并分析血Hcy、CysC与HOMA-IR、HOMA-β的相关性。结果观察组Hcy、CysC、FBG、FINS、HOMA-IR明显高于对照组，两组间HOMA-β无明显差别；Hcy、CysC与HOMA-IR正相关，与HOMA-β无明显相关性。结论GDM患者HOMA-IR、FINS、Hcy、CysC明显升高，Hcy、CysC与HOMA-IR正相关。提示GDM患者存在胰岛素抵抗，血Hcy、CysC水平的测定可作为GDM患者的监测指标。
目的：探討妊娠糖尿病（GDM）患者血清同型半胱氨痠（Hcy）、胱抑素C（CysC）水平的變化及其與胰島功能的關繫。方法選擇2012年1月至2012年12月門診確診的240例GDM患者作為觀察組，100例同期健康孕婦作為對照組。通過對血Hcy、CysC、空腹血糖（FBG）、空腹胰島素（FINS）的測定，比較兩組患者血Hcy、CysC、FBG、FINS、HOMA-IR、HOMA-β水平，併分析血Hcy、CysC與HOMA-IR、HOMA-β的相關性。結果觀察組Hcy、CysC、FBG、FINS、HOMA-IR明顯高于對照組，兩組間HOMA-β無明顯差彆；Hcy、CysC與HOMA-IR正相關，與HOMA-β無明顯相關性。結論GDM患者HOMA-IR、FINS、Hcy、CysC明顯升高，Hcy、CysC與HOMA-IR正相關。提示GDM患者存在胰島素牴抗，血Hcy、CysC水平的測定可作為GDM患者的鑑測指標。
목적：탐토임신당뇨병（GDM）환자혈청동형반광안산（Hcy）、광억소C（CysC）수평적변화급기여이도공능적관계。방법선택2012년1월지2012년12월문진학진적240례GDM환자작위관찰조，100례동기건강잉부작위대조조。통과대혈Hcy、CysC、공복혈당（FBG）、공복이도소（FINS）적측정，비교량조환자혈Hcy、CysC、FBG、FINS、HOMA-IR、HOMA-β수평，병분석혈Hcy、CysC여HOMA-IR、HOMA-β적상관성。결과관찰조Hcy、CysC、FBG、FINS、HOMA-IR명현고우대조조，량조간HOMA-β무명현차별；Hcy、CysC여HOMA-IR정상관，여HOMA-β무명현상관성。결론GDM환자HOMA-IR、FINS、Hcy、CysC명현승고，Hcy、CysC여HOMA-IR정상관。제시GDM환자존재이도소저항，혈Hcy、CysC수평적측정가작위GDM환자적감측지표。
Objective?To explore the changes of homocysteine(Hcy)and cystatin C(CysC) level in the serum of gestational diabetes mellitus patients(GDM), and?the?relationship?between?the?changes?and?islet?function.?Methods?Selecting?240?cases?of?GDM?diagnosed?from?outpatient?from?January?to?December?in?2012?as?a?observation?group,?and?selecting?100?cases?of?healthy?pregnant?women?over?the?same?period?as?a?control?group.?To?determine?Hcy,?CysC,?fasting?blood glucose(FBG)and fasting insulin(FINS)in the blood, and comparing the levels of Hcy, CysC, FBG, FINS, HOMA-IR and HOMA-βin the blood between these two groups. Then analyzing the correlation between Hcy, CysC and HOMA-IR, HOMA-β. Results?The?levels?of?Hcy,?CysC,?FBG,?FINS?and HOMA-IR in the observation group are signiifcantly higher than the ones in the control group. There are no signiifcant differences of HOMA-β’s level between the two groups. The levels of Hcyand CysC are positively correlated with HOMA-IR’s level, but there is no signiifcant correlation with HOMA-β’s level. Conclusions?The levels of Hcy, CysC, FINS and HOMA-IR of GDM patients were signiifcantly increased, and the levels of Hcy and CysC are positively correlated with HOMA-IR’s level. To prompt the GDM patients have insulin resistance. To prompt the determination of the levels of Hcy and CysC in the blood?can?be?the??monitoring?indicators?of?GDM?patients.
