CAJ | 학술논문

目的：观察美金刚（易倍申）和丁苯酞（恩必普）对血管性痴呆（VaD）患者认知和行为功能障碍的改善作用及安全性。方法：将40例VaD患者随机分为美金刚联合丁苯酞治疗组22例（联合治疗组）和美金刚治疗组18例（对照组）。2组患者分别在治疗前和治疗3个月、6个月进行简易精神状态检查（MMSE）以及日常生活能力（ADL）的测评，比较2组的评分结果，并观察不良反应。结果：联合治疗组患者3个月和6个月ADL评分分别为（25.2±5.4）分和（23.2±5.6）分，MMSE评分分别为（18.8±4.4）分和（20.1±4.8）分；对照组患者3个月和6个月ADL评分分别为（26.6±5.9）分和（25.4±6.1）分，MMSE评分分别为（18.1±4.9）分和（18.9±4.7）分。2组与治疗前相比差异均有统计学意义（均P＜0.05）。2组间治疗后6个月比较差异有统计学意义（P＜0.05）。2组均未出现严重不良反应。结论：美金刚和丁苯酞联合应用对VaD的认知功能、行为能力改善效果较单用美金刚明显，并具有较高的安全性。
목적：관찰미금강（역배신）화정분태（은필보）대혈관성치태（VaD）환자인지화행위공능장애적개선작용급안전성。방법：장40례VaD환자수궤분위미금강연합정분태치료조22례（연합치료조）화미금강치료조18례（대조조）。2조환자분별재치료전화치료3개월、6개월진행간역정신상태검사（MMSE）이급일상생활능력（ADL）적측평，비교2조적평분결과，병관찰불량반응。결과：연합치료조환자3개월화6개월ADL평분분별위（25.2±5.4）분화（23.2±5.6）분，MMSE평분분별위（18.8±4.4）분화（20.1±4.8）분；대조조환자3개월화6개월ADL평분분별위（26.6±5.9）분화（25.4±6.1）분，MMSE평분분별위（18.1±4.9）분화（18.9±4.7）분。2조여치료전상비차이균유통계학의의（균P＜0.05）。2조간치료후6개월비교차이유통계학의의（P＜0.05）。2조균미출현엄중불량반응。결론：미금강화정분태연합응용대VaD적인지공능、행위능력개선효과교단용미금강명현，병구유교고적안전성。
Objective: To observe the curative effect and safety of combination of memantine and bu-tylphthalide in the treatment of vascular dementia (VaD), the improvement of the cognitive function and behav-ioral capacity.Methods: Forty cases with VaD were randomly divided into 2 groups: one group treated with memantine and butylphthalide, the other group treated with memantine. MMSE scale and ADL scale of 2 groups were assessed and compared the pre-treatment with the treatment in 3 months, 6 months later. A comparative study was made to evalate the curative effects and side effects between 2 groups.Results: After treating with me-mantine and butylphthaliden for 3 months and 6 months, the ADL scores were (25.2±5.4) and (23.2±5.6) respec-tively, MMSE scores were (18.8±4.4) and (20.1±4.8) respectively. After treatment with memantine for 3 months and 6 months, the ADL scores were (26.6±5.9) and (25.4±6.1) respectively, MMSE scores were (18.1±4.9) and (18.9±4.7) respectively. The data compared pre-treatment with the two groups had statistical signiifcance (P<0.05). The scores of MMSE and ADL after 6 months treatment between two groups have statistical signiif-cance (P<0.05). No serious adverse events was recorded during treatment.Conclusion: Combination of meman-tine and butylphthalide can markedly ameliorate the cognitive function and behavioral abilities in patients with vascular dementia. Its combination with butylphthalide is superior to its single use with high safety.