CAJ | 학술논문

目的：评价窄谱中波紫外线联合地氯雷他定治疗泛发性皮炎湿疹的疗效和安全性。方法：采用非随机同期对照研究方法，将114例泛发性皮炎湿疹患者分为光疗组和激素治疗组，各57例。光疗组应用窄谱中波紫外线联合口服地氯雷他定片，激素治疗组外用糠酸莫米松软膏联合口服地氯雷他定片。光疗组在治疗2、4及8周进行观察记录，激素治疗组在治疗2及4周进行观察记录。治疗结束后进行疗效评分和有效率评价。结果：在治疗2周时，2组比较，激素治疗组疗效评分中位数（3）高于光疗组疗效评分中位数（2）（P＜0.05）；激素治疗组有效率（为38.6%）高于光疗组（为12.3%）（P＜0.05）。在治疗4周时，光疗组疗效评分为4，激素治疗组疗效评分中位数为5（P＞0.05）；光疗组有效率为59.6%，激素治疗组有效率为56.1%（P＞0.05），2组比较差异无统计学意义（P＞0.05）。光疗组2周（2）、4周（4）及8周（6）的疗效评分两两比较差异有统计学意义（P＜0.05）；2周（12.3%）、4周（59.6%）及8周（84.2%）的有效率两两比较差异有统计学意义（P＜0.05）。结论：窄谱中波紫外线联合地氯雷他定治疗泛发性皮炎湿疹安全有效。
목적：평개착보중파자외선연합지록뢰타정치료범발성피염습진적료효화안전성。방법：채용비수궤동기대조연구방법，장114례범발성피염습진환자분위광료조화격소치료조，각57례。광료조응용착보중파자외선연합구복지록뢰타정편，격소치료조외용강산막미송연고연합구복지록뢰타정편。광료조재치료2、4급8주진행관찰기록，격소치료조재치료2급4주진행관찰기록。치료결속후진행료효평분화유효솔평개。결과：재치료2주시，2조비교，격소치료조료효평분중위수（3）고우광료조료효평분중위수（2）（P＜0.05）；격소치료조유효솔（위38.6%）고우광료조（위12.3%）（P＜0.05）。재치료4주시，광료조료효평분위4，격소치료조료효평분중위수위5（P＞0.05）；광료조유효솔위59.6%，격소치료조유효솔위56.1%（P＞0.05），2조비교차이무통계학의의（P＞0.05）。광료조2주（2）、4주（4）급8주（6）적료효평분량량비교차이유통계학의의（P＜0.05）；2주（12.3%）、4주（59.6%）급8주（84.2%）적유효솔량량비교차이유통계학의의（P＜0.05）。결론：착보중파자외선연합지록뢰타정치료범발성피염습진안전유효。
Objective: To evaluate the clinical efifcacy and safety of narrow-band ultraviolet b combined with desloratadine in the treatment of generalized eczema and dermatitis.Methods: Non-randomized concurrent control trial was used to assign 114 patients in UV-treatment group (n=57) and glucocorticoid-treatment group (n=57). Patients in UV-treatment group received the therapy of narrow-band ultraviolet b combined with oral desloratadine. Patients in glucocorticoid-treatment group were topically applied with mometasone furoate oint-ment combined with oral desloratadine. In UV-treatment group, symptom/sign scores were evaluated at the 2th, 4th and 8th week’s end of the treatment. In glucocorticoid-treatment group, symptom/sign scores were evalu-ated at the 2th and 4th week’s end of the treatment. Scores and effective rates were observed after the treatment. Results:After 2 weeks of treatment, the median score of glucocorticoid-treatment group (3) and UV-treatment group (2) had signiifcant difference (P<0.05); the efifcient rate of UV-treatment group (12.3%) and hormones-treatment group (38.6%) had signiifcant difference (P<0.05). After 4 weeks of treatment, the median score of glu-cocorticoid-treatment group (5) and UV-treatment group (4) had no signiifcant difference (P>0.05); the efifcient rate of UV-treatment group (59.6%) and glucocorticoid-treatment group (56.1%) had no signiifcant difference (P>0.05). In UV-treatment group, the median score had signiifcant difference at the 2th (2), 4th (4) and 8th (6) week’s end of the treatment; the efifcient rate had signiifcant difference at the 2th (12.3%), 4th (59.6%) and 8th (84.2%) week’s end of the treatment.Conclusion: The therapy of narrow-band ultraviolet b is safe and effective in the treatment of patients with generalized eczema and dermatitis.