CAJ | 학술논문

肺癌死亡率居全球恶性肿瘤死亡之首，非小细胞肺癌是肺癌中最常见的类型。在传统的抗肺癌治疗中，促进细胞凋亡是非小细胞肺癌治疗的一个重要组成部分，但抗肿瘤药物存在毒副作用大和耐药性等问题。因此，寻找新的抗肿瘤药物作用靶点成为非小细胞肺癌治疗的重点之一。BH3-only蛋白在凋亡的启动及凋亡通路的沟通中发挥极其重要的作用。BIM是BH3-only蛋白家族中的核心成员。以BIM为靶点的治疗在非小细胞肺癌的治疗中具有不可取代的作用。本文简单介绍了BCL-2家族和其中的BH3-only促凋亡蛋白，并且阐述了BIM、BH3-only蛋白在非小细胞肺癌靶向治疗中的重要作用。
폐암사망솔거전구악성종류사망지수，비소세포폐암시폐암중최상견적류형。재전통적항폐암치료중，촉진세포조망시비소세포폐암치료적일개중요조성부분，단항종류약물존재독부작용대화내약성등문제。인차，심조신적항종류약물작용파점성위비소세포폐암치료적중점지일。BH3-only단백재조망적계동급조망통로적구통중발휘겁기중요적작용。BIM시BH3-only단백가족중적핵심성원。이BIM위파점적치료재비소세포폐암적치료중구유불가취대적작용。본문간단개소료BCL-2가족화기중적BH3-only촉조망단백，병차천술료BIM、BH3-only단백재비소세포폐암파향치료중적중요작용。
Lung cancer is the leading cause of cancer deaths throughout the world. Non-small cell lung cancer (NSCLC) is the most common type of lung cancer. In traditional anti-cancer therapy, promotion of apoptosis in NSCLC is an important part of treatment, but anticancer drugs have the toxic side effects, resistance and other problems. hTerefore, the search for new targets of anticancer drugs becomes one of the foci in the treatment of NSCLC. hTe BH3-only protein plays an important role in activation and communication in apoptosis pathways. BIM is the core member in BH3-only protein family. hTe target at BIM in the treatment of NSCLC has an irreplaceable role. hTis paper brielfy describes the BCL-2 family and BH3-only pro-apoptotic protein, elaborates the important role of BIM and BH3-only protein in targeted therapy of NSCLC.