CAJ | 학술논문

目的：观察培美曲塞二线或二线以上治疗老年非小细胞肺癌的疗效及不良反应。方法回顾性分析一线及二线治疗失败的老年非小细胞肺癌21例，应用培美曲塞单药或联合顺铂或卡铂化疗，化疗1个周期后即评价不良反应；化疗2个周期后行疗效评价。结果21例患者中20例可评价疗效，完全缓解（CR）0例，部分缓解（PR）1例，稳定（SD）12例，进展（PD）7例。客观缓解率（ORR）为5%，疾病控制率（DCR）为65%。中位无进展生存期（PFS）为3.5个月。培美曲塞血液学及非血液学副反应均较轻，主要表现为白细胞减少、血小板减少及肝功能异常，经对症及支持处理后能恢复。培美曲塞联合铂类化疗副反应略重。结论老年非小细胞肺癌患者二线或二线以上应用培美曲塞化疗有一定价值，并且副反应轻，老年患者能耐受。
목적：관찰배미곡새이선혹이선이상치료노년비소세포폐암적료효급불량반응。방법회고성분석일선급이선치료실패적노년비소세포폐암21례，응용배미곡새단약혹연합순박혹잡박화료，화료1개주기후즉평개불량반응；화료2개주기후행료효평개。결과21례환자중20례가평개료효，완전완해（CR）0례，부분완해（PR）1례，은정（SD）12례，진전（PD）7례。객관완해솔（ORR）위5%，질병공제솔（DCR）위65%。중위무진전생존기（PFS）위3.5개월。배미곡새혈액학급비혈액학부반응균교경，주요표현위백세포감소、혈소판감소급간공능이상，경대증급지지처리후능회복。배미곡새연합박류화료부반응략중。결론노년비소세포폐암환자이선혹이선이상응용배미곡새화료유일정개치，병차부반응경，노년환자능내수。
Objective To evaluate the efficacy and safety of pemetrexed in the second-line and beyond treatment of advanced non-small cell lung cancer in elderly patients. Methods A total of 21 elderly patients with advanced non-small cell lung cancer were analyzed in the study,who received a combination pemetrexed plus platinum or a single-agent after first-line or multi-line treatment. Results 20 patients were evaluable for short-term efficacy. There were 1 case of partial response,12 cases of stable disease and 7 cases of progressive disease spectively.The overall objective response rate was 5%and the disease control rate was 65%. The median progression-free survival time was 3.5 months. The drug-related adverse events were myelosuppression and liver function damage. Conclusion Administration of pemetrexed after failure of first-line or multi-line treatment is clinically beneficial to elderly patients with advanced non-squamous NSCLC. The toxic effects of the treatment appear to be tolerable.