CAJ | 학술논문

目的：了解荧光素钠注射液致不良反应（ADR）的特点及规律，为临床合理使用提供参考。方法收集某院2012年1月～2013年12月荧光素钠注射液致ADR的报告，并就ADR的相关情况进行总结分析。结果共收集荧光素钠注射液致ADR 84例，不良反应发生率约为2.44%；多为消化系统及皮肤软组织损害，主要表现为恶心、呕吐、皮疹、瘙痒等；3例导致住院的严重不良反应，经抢救脱离危险。结论荧光素钠注射液是一种相对安全的药物，一般ADR较轻微，但也存在发生严重ADR的风险，临床对此应引起重视，做好预防工作，发生不良反应及时处理。
목적：료해형광소납주사액치불량반응（ADR）적특점급규률，위림상합리사용제공삼고。방법수집모원2012년1월～2013년12월형광소납주사액치ADR적보고，병취ADR적상관정황진행총결분석。결과공수집형광소납주사액치ADR 84례，불량반응발생솔약위2.44%；다위소화계통급피부연조직손해，주요표현위악심、구토、피진、소양등；3례도치주원적엄중불량반응，경창구탈리위험。결론형광소납주사액시일충상대안전적약물，일반ADR교경미，단야존재발생엄중ADR적풍험，림상대차응인기중시，주호예방공작，발생불량반응급시처리。
Objective To investigate the characteristics and features of adverse drug reactions(ADRs)induced by Sodium fluorescein injection,and to provide references for rational drug use in clinic.Methods ADRs reports of Sodium fluorescein injection during Jan.2012 to Dec.2013 were collected and analyzed.Results There were 84 cases ofADRs induced by Sodium fluorescein injection,the incidence rate of ADR is 2.44%,most of them were some lesion of gastrointestinal or skin and soft tissue injury,manifesting as nausea and vomiting,rash combinedwith itching.3 cases of serious ADRs lead to hospitalizationwere out of danger after rescue.Conclusions Sodium fluorescein injection is a relatively safe drug,ADRs are generally mild.However,several serious ADRs may also occur,much attention should be paid for the purpose of a precaution and timely managing of ADRs.