CAJ | 학술논문

目的：探讨同型半胱氨酸浓度水平的检测对于早期诊断急性心肌梗死的应用价值。方法选择2013年1月～2013年12月确诊为冠心病的患者53例为试验组，选择同期进行体检且结果显示为健康的50例为对照组，试验组和对照组均进行同型半胱氨酸、肌酸激酶、肌酸激酶同工酶的测定，对结果进行综合分析。结果试验组的患者血清同型半胱氨酸、肌酸激酶、肌酸激酶同工酶的浓度水平较对照组均有明显上升趋势，差异有统计学意义（P＜0.05）；阳性检出率分析，试验组患者的的同型半胱氨酸、肌酸激酶和肌酸激酶同工酶的检测结果阳性率分别为84.91%（45/53）、81.13%（43/53）、83.02%（44/53），同型半胱氨酸检测结果阳性率分别与肌酸激酶、肌酸激酶同工酶两两比较，差异无统计学意义（P＞0.05）；临床标本相关性分析，同型半胱氨酸检测结果和临床诊断结果的相关性好，Kappa值等于0.81。结论同型半胱氨酸是一种辅助诊断冠心病的有效指标，具有较好的灵敏度和临床符合性。
목적：탐토동형반광안산농도수평적검측대우조기진단급성심기경사적응용개치。방법선택2013년1월～2013년12월학진위관심병적환자53례위시험조，선택동기진행체검차결과현시위건강적50례위대조조，시험조화대조조균진행동형반광안산、기산격매、기산격매동공매적측정，대결과진행종합분석。결과시험조적환자혈청동형반광안산、기산격매、기산격매동공매적농도수평교대조조균유명현상승추세，차이유통계학의의（P＜0.05）；양성검출솔분석，시험조환자적적동형반광안산、기산격매화기산격매동공매적검측결과양성솔분별위84.91%（45/53）、81.13%（43/53）、83.02%（44/53），동형반광안산검측결과양성솔분별여기산격매、기산격매동공매량량비교，차이무통계학의의（P＞0.05）；림상표본상관성분석，동형반광안산검측결과화림상진단결과적상관성호，Kappa치등우0.81。결론동형반광안산시일충보조진단관심병적유효지표，구유교호적령민도화림상부합성。
Objective To explore the clinical significance of the Homocysteine testing in the Coronary atherosclerotic heart disease . Methods Choosing 53 cases of patients with the Coronary atherosclerotic heart disease for the experimental group,and 50 cases of healthy check-up for the control group,testing the Homocysteine,Creatine Kinase and MB Iso Enzyme of Creatine Kinase,analyze the results comprehensively. Results Compared with the control group, there were significantly higher of the experimental group of the Homocysteine,Creatine Kinase and MB Iso Enzyme of Creatine Kinase results(P<0.05). The positive rate of the Homocysteine,Creatine Kinase and MB Iso Enzyme of Creatine Kinase was 84.91%,81.13%,83.02%,but there were no significantly difference between the Homocysteine and Creatine Kinase or Homocysteine and MB Iso Enzyme of Creatine Kinase(P > 0.05). Clinical specimens correlation analysis results show that the Homocysteine and the correlation of clinical diagnosis result is good(Kappa=0.81). Conclusion There is a good indicators for the Coronary atherosclerotic heart disease diagnosis of the Homocysteine,which has good positive rate and clinical compliance.