临床肝胆病杂志
臨床肝膽病雜誌
림상간담병잡지
CHINESE JOURNAL OF CLINICAL HEPATOLOGY
2014年
11期
1176-1178
,共3页
刘惠媛%应若素%陈志敏%廖宝林%许敏
劉惠媛%應若素%陳誌敏%廖寶林%許敏
류혜원%응약소%진지민%료보림%허민
妊娠并发症,感染性%肝炎,病毒性,人%肝炎病毒,乙型
妊娠併髮癥,感染性%肝炎,病毒性,人%肝炎病毒,乙型
임신병발증,감염성%간염,병독성,인%간염병독,을형
pregnancy complications,infectious%hepatitis,viral,human%hepatitis B virus
目的:了解妊娠期病毒性肝炎的临床特点。方法回顾性分析2009年1月至2013年3月于广州市第八人民医院因病毒性肝炎住院的77例妊娠妇女的临床资料,分析肝炎病因、血清病毒学特点、肝损害程度与孕期的相关性。计量资料的组间比较采用Kruskal-Wallis H检验。结果病因:乙型肝炎多见,共72例(93.51%),有10.27%患者感染甲、乙或戊型肝炎病毒所致急性病毒性肝炎;肝损害程度:中度肝损害64例(83.12%),重度肝损害7例(9.09%),肝衰竭3例(3.90%);肝炎发作时孕期:妊娠早期16例(20.78%),妊娠中期49例(63.64%),妊娠晚期12例(15.58%);肝功能指标:总胆汁酸(TBA)、TBil、白蛋白(Alb)、ALT、AST、凝血酶原活动度(PTA)在HBeAg阳性和阴性患者间,以及在HBV DNA>106 IU/ml和HBV DNA≤106 IU/ml患者间差异均无统计学意义(P>0.05)。结论妊娠期病毒性肝炎主要由HBV引起,多数引起中度肝损害,重度肝损害或肝衰竭常发生于妊娠中晚期,因此育龄妇女妊娠期须注意防治慢性乙型肝炎。
目的:瞭解妊娠期病毒性肝炎的臨床特點。方法迴顧性分析2009年1月至2013年3月于廣州市第八人民醫院因病毒性肝炎住院的77例妊娠婦女的臨床資料,分析肝炎病因、血清病毒學特點、肝損害程度與孕期的相關性。計量資料的組間比較採用Kruskal-Wallis H檢驗。結果病因:乙型肝炎多見,共72例(93.51%),有10.27%患者感染甲、乙或戊型肝炎病毒所緻急性病毒性肝炎;肝損害程度:中度肝損害64例(83.12%),重度肝損害7例(9.09%),肝衰竭3例(3.90%);肝炎髮作時孕期:妊娠早期16例(20.78%),妊娠中期49例(63.64%),妊娠晚期12例(15.58%);肝功能指標:總膽汁痠(TBA)、TBil、白蛋白(Alb)、ALT、AST、凝血酶原活動度(PTA)在HBeAg暘性和陰性患者間,以及在HBV DNA>106 IU/ml和HBV DNA≤106 IU/ml患者間差異均無統計學意義(P>0.05)。結論妊娠期病毒性肝炎主要由HBV引起,多數引起中度肝損害,重度肝損害或肝衰竭常髮生于妊娠中晚期,因此育齡婦女妊娠期鬚註意防治慢性乙型肝炎。
목적:료해임신기병독성간염적림상특점。방법회고성분석2009년1월지2013년3월우엄주시제팔인민의원인병독성간염주원적77례임신부녀적림상자료,분석간염병인、혈청병독학특점、간손해정도여잉기적상관성。계량자료적조간비교채용Kruskal-Wallis H검험。결과병인:을형간염다견,공72례(93.51%),유10.27%환자감염갑、을혹무형간염병독소치급성병독성간염;간손해정도:중도간손해64례(83.12%),중도간손해7례(9.09%),간쇠갈3례(3.90%);간염발작시잉기:임신조기16례(20.78%),임신중기49례(63.64%),임신만기12례(15.58%);간공능지표:총담즙산(TBA)、TBil、백단백(Alb)、ALT、AST、응혈매원활동도(PTA)재HBeAg양성화음성환자간,이급재HBV DNA>106 IU/ml화HBV DNA≤106 IU/ml환자간차이균무통계학의의(P>0.05)。결론임신기병독성간염주요유HBV인기,다수인기중도간손해,중도간손해혹간쇠갈상발생우임신중만기,인차육령부녀임신기수주의방치만성을형간염。
Objective To study the clinical characteristics of viral hepatitis in pregnancy.Methods A retrospective analysis was per-formed on 77 pregnant women with viral hepatitis who were admitted to our hospital from January 2009 to March 2013.Cause of hepatitis,se-rologic and virologic markers,degree of liver damage,and association with the stage of pregnancy were analyzed.Comparison of continuous data between groups was made by Kruskal-Wallis H test.Results The main cause of viral hepatitis in pregnancy was HBV infection (72 cases,93.51%),and 10.27%of patients were infected with hepatitis A,B or E virus.Moderate liver damage was detected in 64 patients (83.12%),severe liver damage in 7 patients (9.09%),and liver failure in 3 patients (3.90%).Sixteen patients (20.78%)were diag-nosed with hepatitis in the first trimester of pregnancy,49 (63.64%)in the second trimester,and 12 (15.58%)in the third trimester. Liver function indices,including total bile acid (TBA),total bilirubin (TBil),albumin (Alb),alanine aminotransferase (ALT),aspar-tate transaminase (AST),and prothrombin activity (PTA),were compared between HBeAg (+)and HBeAg (-)patients and between patients with HBV DNA >106 IU/ml and ≤106 IU/ml,and no significant differences were found in either comparison (P>0.05).Con-clusion Viral hepatitis in pregnancy is mainly caused by infection with hepatitis B virus.Liver damage is mostly moderate and severe liver damage and liver failure often occur in the middle or late stage of pregnancy.This study indicates that pregnant women should take precau-tions and active treatment for chronic hepatitis B.