化学研究与应用
化學研究與應用
화학연구여응용
CHEMICAL RESEARCH AND APPLICATION
2014年
11期
1788-1792
,共5页
宋志国%宋吉磊%孙啸虎%杨喜宝
宋誌國%宋吉磊%孫嘯虎%楊喜寶
송지국%송길뢰%손소호%양희보
3,4-二氢嘧啶-2(1H)-酮%氯化镉%一锅法%Biginelli-like反应
3,4-二氫嘧啶-2(1H)-酮%氯化鎘%一鍋法%Biginelli-like反應
3,4-이경밀정-2(1H)-동%록화력%일과법%Biginelli-like반응
3,4-dihydropyrimidin-2(1H)-ones%cadium chloride%one-pot synthesis%Biginelli-like reaction
在氯化镉催化作用下,以环己烷为溶剂,芳香醛、芳香酮和脲三组分“一锅法”合成了一系列4,6-二芳基-3,4-二氢嘧啶-2(1H)-酮化合物。考察了溶剂和催化剂用量对产率的影响。通过IR、1 H NMR、13 C NMR和元素分析对产品结构进行了表征。该合成方法具有操作简单、反应时间短、反应条件温和,产率高等优点。
在氯化鎘催化作用下,以環己烷為溶劑,芳香醛、芳香酮和脲三組分“一鍋法”閤成瞭一繫列4,6-二芳基-3,4-二氫嘧啶-2(1H)-酮化閤物。攷察瞭溶劑和催化劑用量對產率的影響。通過IR、1 H NMR、13 C NMR和元素分析對產品結構進行瞭錶徵。該閤成方法具有操作簡單、反應時間短、反應條件溫和,產率高等優點。
재록화력최화작용하,이배기완위용제,방향철、방향동화뇨삼조분“일과법”합성료일계렬4,6-이방기-3,4-이경밀정-2(1H)-동화합물。고찰료용제화최화제용량대산솔적영향。통과IR、1 H NMR、13 C NMR화원소분석대산품결구진행료표정。해합성방법구유조작간단、반응시간단、반응조건온화,산솔고등우점。
4,6-Diaryl-3,4-dihydropyrimidin-2(1H)-ones were synthesized by a three components one-pot reaction of aromatic alde-hydes,aromatic ketones and urea in the presence of cadium chloride in cyclohexane. The effects of solvents and amount of catalysts on the yields were investigated. The structures of products were characterized by IR,1 H NMR,13 C NMR and elemental analysis. The method had advantages of simple work-up,short reaction time,mild conditions,and high yields.
