CAJ | 학술논문

本文研究了盐酸环丙沙星(Cipro)在导电碳黑糊电极上的伏安行为,结果表明：B-R缓冲溶液(pH 4．0)中,该药物分子发生2质子、2电子转移的不可逆电化学氧化,过程受吸附控制,电子转移系数α为0．37,表面反应标准速率常数k′s为0．95 s-1。实验研究了支持电解质种类、pH值、离子强度、富集电位与时间等对其伏安响应的影响,并据结果对检测条件进行优化,进而建立了Cipro的电化学检测方法。优化条件下,Cipro的氧化峰电流(ipa)与其浓度(C0)在2．5×10-7~6．0×10-5 mol·L-1范围内呈良好的线性关系,检测限为9．5×10-8 mol·L-1(S/N=3)。将该方法应用于测定淡水渔业水样中痕量 Cipro,得到了较满意的结果(平均回收率102．73%)。
본문연구료염산배병사성(Cipro)재도전탄흑호전겁상적복안행위,결과표명：B-R완충용액(pH 4．0)중,해약물분자발생2질자、2전자전이적불가역전화학양화,과정수흡부공제,전자전이계수α위0．37,표면반응표준속솔상수k′s위0．95 s-1。실험연구료지지전해질충류、pH치、리자강도、부집전위여시간등대기복안향응적영향,병거결과대검측조건진행우화,진이건립료Cipro적전화학검측방법。우화조건하,Cipro적양화봉전류(ipa)여기농도(C0)재2．5×10-7~6．0×10-5 mol·L-1범위내정량호적선성관계,검측한위9．5×10-8 mol·L-1(S/N=3)。장해방법응용우측정담수어업수양중흔량 Cipro,득도료교만의적결과(평균회수솔102．73%)。
The electrochemical behaviors of ciprofloxacin hydrochloride(Cipro)were investigated by voltammetry using conductive carbon black paste electrode as working electrode. Results indicate that an irreversible adsorption-controlled oxidation reaction of Cipro occurre in the B-R buffer solution of pH 4. 0 with two protons and two electrons transfer. The electron transfer coefficientαis 0. 37 and the standard surface reaction rate constant k′s is 0. 95 s-1 . Effect factors,including species of the supporting electrolyte, pH,ionic strength of supporting electrolyte,accumulation potential and accumulation time,were studied and optimized. Under the optimal conditions,there is a linear relationship between the oxidative peak current of Cipro and its concentration over the range of 2. 5 × 10-7 ~6. 0 × 10-5 mol·L-1 with a detection limit of 9. 5 × 10-8 mol·L-1(signal/noise=3). The method was applied to de-termine trace Cipro in real fishery water samples. And the outcomes were satisfactory with an average recovery rate of 102. 73%.