CAJ | 학술논문

1,2,3-三氮唑衍生物是近些年研究热点化合物之一,随着4-单取代型衍生物在医药、农药、材料等领域的广泛应用,该类化合物的合成及应用近些年引起了广大研究者的关注并获得了可喜进展。本文阐述了4-单取代-1,2,3-三氮唑衍生物的合成发展历史,着重综述了近十年来该类唑衍生物的合成发展情况。内容主要包括末端炔的环加成反应、由取代烯烃合成法及由3-芳基-2,3-二溴丙酸合成法。文章还包括一些合成方法及其产物的应用,并对一些重要的反应机理做了分析。文章最后对该类化合物的合成做了总结并展望了未来发展方向。
1,2,3-삼담서연생물시근사년연구열점화합물지일,수착4-단취대형연생물재의약、농약、재료등영역적엄범응용,해류화합물적합성급응용근사년인기료엄대연구자적관주병획득료가희진전。본문천술료4-단취대-1,2,3-삼담서연생물적합성발전역사,착중종술료근십년래해류서연생물적합성발전정황。내용주요포괄말단결적배가성반응、유취대희경합성법급유3-방기-2,3-이추병산합성법。문장환포괄일사합성방법급기산물적응용,병대일사중요적반응궤리주료분석。문장최후대해류화합물적합성주료총결병전망료미래발전방향。
1,2,3-Trizaole derivatives had become a research focus in recent years. Much attention had been paid to the synthesis of 4-monosubstituted-1,2,3-trizaole derivatives with the development of their wide applications in the fields of medicine,pesticide,and materials. This review mainly described the synthesis history of these derivatives,focusing on the methods of cycloaddition reaction of terminal alkynes,preparation from substituted alkenes,and preparation from 3-aryl-2,3-dibromopropanoic acids in recent 10 years. Relevant mechanisms and applications of some reactions and their products were also described. Finally,the further work nee-ded to do and the development trends in the field of the synthesis of 4-monosubstituted-1,2,3-triazole derivatives were proposed.