CAJ | 학술논문

为了制备得到高纯度的罗汉果醇以及阐明罗汉果醇的代谢特点，采用酸水解法从粗罗汉果皂苷 V (含量50％)制备得到高纯度的罗汉果醇，用大鼠灌胃给药(100 mg??kg-1)方法以及通过 HPLC-ESI-IT-TOF-MSn研究罗汉果醇的代谢特点。结果表明：在粪便中能发现较多氧化产物，在血浆中也能检测到代谢产物。说明罗汉果醇灌胃给药后，能经过吸收和代谢进入血液从而发生作用。
위료제비득도고순도적라한과순이급천명라한과순적대사특점，채용산수해법종조라한과조감 V (함량50％)제비득도고순도적라한과순，용대서관위급약(100 mg??kg-1)방법이급통과 HPLC-ESI-IT-TOF-MSn연구라한과순적대사특점。결과표명：재분편중능발현교다양화산물，재혈장중야능검측도대사산물。설명라한과순관위급약후，능경과흡수화대사진입혈액종이발생작용。
Mogrosides are main active ingredients in Siraitia grosvenorii ,and the mogrol is the mogrosides’common aglycon,but few research on metabolism of mogrosides.So in order to prepare and get much high purity mogrol,50%mogroside V by acid hydrolysis were prepared,and its in vivo metabolism in rats was studied by HPLC-ESI-IT-TOF-MSn after oral administration at the dose of 100 mg??kg-1 .we collected the blank and drug feces and plasma,the re-sults implied that mogrol could be absorbed into the blood of rats.A lot of oxidation metabolites of mogrol were de-tected in feces samples,and some were also detected in plasma samples.So,we will do the study continuously,and provided the scientific basis for its application and development in future.