CAJ | 학술논문

微小RNA（microRNA，miRNA）是一类内源性非编码调节性小RNA，通过与3′非转录区（3′UTR）互补配对来调节其靶基因的蛋白翻译或者mRNA降解过程，从而在转录后水平调节靶基因的表达。成熟的miRNA通过调节靶基因的表达行使其生物学功能，参与细胞增长、细胞凋亡等多种细胞癌变过程。研究表明，miRNA在宫颈癌中的差异性表达有可能使其成为诊断、临床病理学特征和评价预后的新指标。miRNA也可以用于指导治疗以及成为治疗用药的靶点，为临床应用提供广泛前景。
미소RNA（microRNA，miRNA）시일류내원성비편마조절성소RNA，통과여3′비전록구（3′UTR）호보배대래조절기파기인적단백번역혹자mRNA강해과정，종이재전록후수평조절파기인적표체。성숙적miRNA통과조절파기인적표체행사기생물학공능，삼여세포증장、세포조망등다충세포암변과정。연구표명，miRNA재궁경암중적차이성표체유가능사기성위진단、림상병이학특정화평개예후적신지표。miRNA야가이용우지도치료이급성위치료용약적파점，위림상응용제공엄범전경。
MicroRNA (miRNA), a class of endogenous small non-coding regulatory RNAs, regulate the expression of target genes by pairing with its 3′untranslated regions (3′UTR) to induce the inhibited translation or mRNA degression. Mature miRNA may interfere with multiple biological processes involved in tumorigenesis such as cell proliferation, cell cycle, apoptosis, angiogenesis, invasion and metastasis. Multiple studies showed that the aberrant expression of miRNA, as novel potential makers, could provide numerous promising merits in diagnostic, pathological and therapeutic targets in cervical cancer.