CAJ | 학술논문

青光眼是全球第二大致盲疾病，眼压增高是其主要危险因素，前列腺素类药物是新型的抗青光眼药物，广泛应用于临床，但其药物反应个体差异大，对其原因尚不明确，遗传变异可能是造成个体间反应差异的主要原因之一。本文对其可能的原因进行总结，希望能对临床个体化治疗和研究提供帮助。
청광안시전구제이대치맹질병，안압증고시기주요위험인소，전렬선소류약물시신형적항청광안약물，엄범응용우림상，단기약물반응개체차이대，대기원인상불명학，유전변이가능시조성개체간반응차이적주요원인지일。본문대기가능적원인진행총결，희망능대림상개체화치료화연구제공방조。
Glaucoma is the world′s second largest cause of blindness , and increased intraocular pressure is the main risk factor.Prostaglandin analogues are a new category drug as antiglaucoma agents , widely used in clinical, but there are large individual differences in drug response.The reason is still unclear.Genetic variation may be one of the main reasons for differences between individuals.This review will summarize the possi-ble reasons , hoping to provide help for clinical individual therapy and re-search.