CAJ | 학술논문

妊娠妇女肥胖与流产之间的关系日益受到关注。对于因不孕接受治疗的女性，肥胖者发生流产的机会增加。肥胖女性应在体质量得到有效控制后再考虑妊娠；对于自然妊娠的女性，肥胖亦会增加流产风险。多数研究表明，肥胖导致的内分泌功能紊乱是引发流产的主要机制，肥胖患者多数存在高胰岛素血症及胰岛素抵抗（IR），其中Ⅰ型纤溶酶原激活剂抑制物（PAI-1）、雄激素、胰岛素样生长因子等分别在发病机制中起不同作用。另外，子宫内膜容受性降低、子宫内膜血流减少、染色体核型异常等也是肥胖导致流产的原因。综述肥胖在流产中的作用机制。
임신부녀비반여유산지간적관계일익수도관주。대우인불잉접수치료적녀성，비반자발생유산적궤회증가。비반녀성응재체질량득도유효공제후재고필임신；대우자연임신적녀성，비반역회증가유산풍험。다수연구표명，비반도치적내분비공능문란시인발유산적주요궤제，비반환자다수존재고이도소혈증급이도소저항（IR），기중Ⅰ형섬용매원격활제억제물（PAI-1）、웅격소、이도소양생장인자등분별재발병궤제중기불동작용。령외，자궁내막용수성강저、자궁내막혈류감소、염색체핵형이상등야시비반도치유산적원인。종술비반재유산중적작용궤제。
Gestational obesity and correlative abortion are becoming the focus. In those infertile women, obese women have higher risk of abortion. So, obese women are suggested to control well their weight before pregnancy. In those women with natural pregnancy, obese women have also increased risk of abortion. Most studies showed that the endocrine disorders related with obesity were the main mechanism of abortion. Most obese patients are accompanied with hyperinsulinism and insulin resistance, while the plasminogen activator inhibitor-1 (PAI-1), androgen and insulin-like growth factor play different roles in the pathophysiology. In addition, the decreased uterine receptivity, the reduced endometrial blood flow and abnormal karyotype are reasons of abortion in obese women. In this paper, the mechanism of abortion in obese women was reviewed.