CAJ | 학술논문

目的：探讨宫腔内人工授精（IUI）在子宫内膜异位症（EMs）不孕患者腹腔镜术后半年的应用价值。方法：选择2010年1月-2012年12月在中山大学附属中山市人民医院不孕专科门诊就诊，经过常规系统检查后，行腹腔镜手术诊断为Ⅰ~Ⅲ期EMs并已进行手术治疗的不孕妇女98例，按患者意愿分为期待组42例、自然周期+宫腔内人工授精（NC+IUI）组38例、控制性促排卵+宫腔内人工授精（COS+IUI）组18例。比较术后半年的妊娠情况。结果：期待组周期妊娠率6.1%（12/197），半年累积妊娠率28.6%（12/42）。NC+IUI组周期妊娠率6.6%（4/61），半年累积妊娠率10.5%（4/38）。 COS+IUI组周期妊娠率14.8%（4/27），半年累积妊娠率22.2%（4/18）。3组周期妊娠率和累积妊娠率比较，差异无统计学意义（P＞0.05）。结论：Ⅰ~Ⅲ期EMs不孕患者术后半年积极给予IUI的妊娠率与期待治疗相当，但此结论有待增加样本量进一步探讨。
목적：탐토궁강내인공수정（IUI）재자궁내막이위증（EMs）불잉환자복강경술후반년적응용개치。방법：선택2010년1월-2012년12월재중산대학부속중산시인민의원불잉전과문진취진，경과상규계통검사후，행복강경수술진단위Ⅰ~Ⅲ기EMs병이진행수술치료적불잉부녀98례，안환자의원분위기대조42례、자연주기+궁강내인공수정（NC+IUI）조38례、공제성촉배란+궁강내인공수정（COS+IUI）조18례。비교술후반년적임신정황。결과：기대조주기임신솔6.1%（12/197），반년루적임신솔28.6%（12/42）。NC+IUI조주기임신솔6.6%（4/61），반년루적임신솔10.5%（4/38）。 COS+IUI조주기임신솔14.8%（4/27），반년루적임신솔22.2%（4/18）。3조주기임신솔화루적임신솔비교，차이무통계학의의（P＞0.05）。결론：Ⅰ~Ⅲ기EMs불잉환자술후반년적겁급여IUI적임신솔여기대치료상당，단차결론유대증가양본량진일보탐토。
Objective: To investigate the clinical outcomes of intrauterine insemination (IUI) in infertility women with endometriosis in half year after laparoscopic treatment. Methods:Ninety-eight patients with endometriosis (stage Ⅰ-Ⅲ) treated by laparoscopy, from January 2010 to December 2012 at Zhongshan People′s Hospital, were divided into three groups: nature cycle plus IUI (NC+IUI), controlled ovarian hyperstimulation plus IUI (COS+IUI), and expectant treatment without IUI (ET control), with the informed consent. The pregnancy rates of three groups in half year after operation were compared. Results:The pregnancy rate per cycle, and the cumulative pregnancy rate in half a year were 6.1%(12/197) and 28.6%(12/42) in the ET control group, 6.6%(4/61) and 10.5%(4/38) in the NC+IUI group, and 14.8%(4/27) and 22.2%(4/18) in the COS+IUI group. Interestingly, there were no significant differences in those rates among three groups (P>0.05). Conclusions:There is not significant difference in the pregnancy rate in those infertility patients with endometriosis (stage I-III) in half year after the laparoscopic treatment combined with IUI and without IUI (expectant treatment). Of course, it is necessary to study further with more samples.