CAJ | 학술논문

目的：观察急性脑梗死患者血清超敏C反应蛋白水平与病情发展及演变的关系。方法急性脑梗死患者（151例）作为试验组，依据神经功能缺损程度再分为轻、中、重型3个亚组；选取健康者作为对照组（151例）。试验组进行常规治疗（低分子右旋糖酐250 mL连续7 d、丹红注射液4 mL连续14 d、5％碳酸氢钠250 mL连续3 d；视情况予以肝素总量不超过12500 u抗凝）。2组均进行血清超敏C反应蛋白（ hs-CRP）、D-二聚体及低密度脂蛋白胆固醇（ LDL-C）水平监测。比较2组血清hs-CRP水平与急性脑梗死严重程度的关系。结果急性脑梗死患者，血清 hs -CRP 水平、D-二聚体阳性率均明显高于对照组（ P＜0.05）；其hs-CRP与神经系统损伤评分呈高度正相关（ P＜0.05）；其D-二聚体水平与神经系统损伤评分也呈正相关（ P＜0.05）。结论 hs-CRP水平可以独立反映脑梗死疾病的发生发展，与病情有相关性。
목적：관찰급성뇌경사환자혈청초민C반응단백수평여병정발전급연변적관계。방법급성뇌경사환자（151례）작위시험조，의거신경공능결손정도재분위경、중、중형3개아조；선취건강자작위대조조（151례）。시험조진행상규치료（저분자우선당항250 mL련속7 d、단홍주사액4 mL련속14 d、5％탄산경납250 mL련속3 d；시정황여이간소총량불초과12500 u항응）。2조균진행혈청초민C반응단백（ hs-CRP）、D-이취체급저밀도지단백담고순（ LDL-C）수평감측。비교2조혈청hs-CRP수평여급성뇌경사엄중정도적관계。결과급성뇌경사환자，혈청 hs -CRP 수평、D-이취체양성솔균명현고우대조조（ P＜0.05）；기hs-CRP여신경계통손상평분정고도정상관（ P＜0.05）；기D-이취체수평여신경계통손상평분야정정상관（ P＜0.05）。결론 hs-CRP수평가이독립반영뇌경사질병적발생발전，여병정유상관성。
Objective To investigate the relationship between the serum high-sensitivity C-reactive protein level and the situation of the acute cerebral infarction.Methods The trial group was made up of 151 diag-nosed patients with acute cerebral infarction in our hospital and in ac-cordance with the degree of neurological deficit score , they were divided into light , medium and heavy -duty groups.Patients in the trial group were given intravenous dextran 250 mL for 7 consecutive days , Danhong injection 250 mL for 14 days, 5%sodium bicarbonate 250 mL for 3 con-secutive days , and depending on the patient's condition , no more than 12 ,500 units of heparin were given.The control group were 151 random samples from the hospital medical center health personnel.The serum high-sensitivity C-reactive protein , D-dimer and low -density lipo-protein-C ( LDL-C) level monitoring in both groups were carried out.Then the two groups were compared.The relationship between serum high-sensitivity C-reactive protein level and severity of acute cerebral infarction was analyzed.Results The positive rate and serum levels with serum hypersensitive C -reactive protein and D-dimer in patients with acute cerebral infarction were higher than those of the control group , with statistical difference ( P<0.05 ) .Hs CRP and nervous system damage score were high positive correlation ( P<0.05 ) .D-dimer level score was positively correlated with nervous system damage ( P <0.05 ). Conclusion The high sensitivity C -reactive protein level can reflect the incidence and development of cerebral dis-ease independently , and the disease associated with prognosis and close monitoring of high sensitivity C -reactive pro-tein level on the prognosis of significance.