CAJ | 학술논문

目的：研究中药降压茶对肝经郁热证高血压前期患者中医证候疗效及临床转归的影响，并观察其安全性。方法入选150例肝经郁热证高血压前期患者，随机分为对照组、生活方式干预组(干预组)、治疗组(生活方式干预+中药降压茶组)，各50例，对治疗后各组中医证候疗效及临床转归进行分析。结果中医证候疗效：与对照组比较，干预组及治疗组显效率、有效率及总有效率均明显升高，无效和加重比例明显降低，差异有统计学意义(P <0.05)；与干预组比较，治疗组显效率、总有效率明显升高，无效比例明显降低，差异有统计学意义(P <0.05)。3组临床转归：与对照组比较，干预组及治疗组进展为高血压的比例明显降低，达到理想血压的比例明显升高，差异有统计学意义(P <0.05)；与干预组比较，治疗组进展为高血压的比例有下降趋势，但差异无统计学意义，达到理想血压的比例明显升高，差异有统计学意义(P <0.05)；各组治疗后均未发现明显不良反应。结论在生活方式干预基础上加用中药降压茶治疗能够明显改善肝经郁热证高血压前期患者的中医证候，能够明显延缓肝经郁热证高血压前期患者发展为高血压的进程。
목적：연구중약강압다대간경욱열증고혈압전기환자중의증후료효급림상전귀적영향，병관찰기안전성。방법입선150례간경욱열증고혈압전기환자，수궤분위대조조、생활방식간예조(간예조)、치료조(생활방식간예+중약강압다조)，각50례，대치료후각조중의증후료효급림상전귀진행분석。결과중의증후료효：여대조조비교，간예조급치료조현효솔、유효솔급총유효솔균명현승고，무효화가중비례명현강저，차이유통계학의의(P <0.05)；여간예조비교，치료조현효솔、총유효솔명현승고，무효비례명현강저，차이유통계학의의(P <0.05)。3조림상전귀：여대조조비교，간예조급치료조진전위고혈압적비례명현강저，체도이상혈압적비례명현승고，차이유통계학의의(P <0.05)；여간예조비교，치료조진전위고혈압적비례유하강추세，단차이무통계학의의，체도이상혈압적비례명현승고，차이유통계학의의(P <0.05)；각조치료후균미발현명현불량반응。결론재생활방식간예기출상가용중약강압다치료능구명현개선간경욱열증고혈압전기환자적중의증후，능구명현연완간경욱열증고혈압전기환자발전위고혈압적진정。
Objective To explore clinical effects and outcomes of antihypertensive tea in treating prehypertensive patients with stagnated heat of liver meridian syndrome,and observes its safety.Methods One hundred and fifty prehypertensive patients with stagnated heat of liver meridian syndrome were randomly divided into control group,life style intervention group and drug therapy group,50 patients in each group.Based on life style intervention,drug therapy group were added Chinese medicine of antihypertensive tea.Therapy effects and clinical outcome of three groups were observed.Results For traditional Chinese medicine(TCM)syndrome, compared with control group,significant efficiency,effective rate and total effective rate in life style intervention group and drug thera-py group were obviously higher than control group,while inefficiency,increase ratio were lower than control group,and had significant meaning among three groups(P <0.05 ).Compared with life style intervention group,effective rate and total effective rate in drug therapy group were obviously higher,while inefficiency,increase ratio were lower,and has significant differences between two groups (P <0.05).For clinical outcome,compared with control group,the ratio of life style intervention group and drug therapy group devel-oped to hypertension was lower than control group,while the ratio of obtained to satisfied blood press was obviously increase,and had significant differences among three groups(P <0.05).Compared with life style intervention group,the ratio of life drug therapy group developed to hypertension was lower than life style intervention,but no significant meaning between two groups,while there was obvi-ous differences in ratio of obtained to satisfied blood press between two groups(P <0.05 ).There was no side effect occurred after treatment.Conclusion Antihypertensive tea based on life style intervention can obviously improve TCM syndrome of prehypertens-ive patients with stagnated heat of liver meridian syndrome,and delay the progress for hypertension.