医学检验与临床
醫學檢驗與臨床
의학검험여림상
MEDICAL LATORATORY SCIENCE AND CLINICES
2014年
5期
55-56,18
,共3页
林上忠%黄丽华%余养生
林上忠%黃麗華%餘養生
림상충%황려화%여양생
恶性肿瘤%化疗%未成熟网织红细胞指数%网织红细胞百分数%白细胞计数%血小板计数
噁性腫瘤%化療%未成熟網織紅細胞指數%網織紅細胞百分數%白細胞計數%血小闆計數
악성종류%화료%미성숙망직홍세포지수%망직홍세포백분수%백세포계수%혈소판계수
Malignant tumor%Chemotherapy%Immature reticulocyte index%The percentage of reticulocyte%White blood cell count%Platelet count
目的：探讨恶性肿瘤病人化疗过程中未成熟网织红细胞指数（IRF）和相关参数的变化及其临床意义。方法：采用Sysmex XN-9000全自动血细胞分析仪对51例恶性肿瘤患者化疗前后外周血未成熟网织红细胞指数(IRF)、网织红细胞百分数（Ret%）、白细胞计数(WBC)和血小板计数（PLT）进行动态检测。结果：化疗后第3天， IRF和Ret%出现明显下降，差异有统计学意义（Р<0.01），IRF第6天降到最低，第10天有所回升，Ret%第10天降到最低，第15天IRF和Ret%明显上升，差异有统计学意义（Р<0.01）；WBC和PLT在化疗后第6天出现明显下降，差异有统计学意义（Р<0.01），第15天降到最低，第20天较第15天出现上升，差异有统计学意义(Р<0.05)。结论：未成熟网织红细胞指数及相关参数可作为检测恶性肿瘤患者化疗期间骨髓造血功能抑制和恢复的早期敏感指标。
目的：探討噁性腫瘤病人化療過程中未成熟網織紅細胞指數（IRF）和相關參數的變化及其臨床意義。方法：採用Sysmex XN-9000全自動血細胞分析儀對51例噁性腫瘤患者化療前後外週血未成熟網織紅細胞指數(IRF)、網織紅細胞百分數（Ret%）、白細胞計數(WBC)和血小闆計數（PLT）進行動態檢測。結果：化療後第3天， IRF和Ret%齣現明顯下降，差異有統計學意義（Р<0.01），IRF第6天降到最低，第10天有所迴升，Ret%第10天降到最低，第15天IRF和Ret%明顯上升，差異有統計學意義（Р<0.01）；WBC和PLT在化療後第6天齣現明顯下降，差異有統計學意義（Р<0.01），第15天降到最低，第20天較第15天齣現上升，差異有統計學意義(Р<0.05)。結論：未成熟網織紅細胞指數及相關參數可作為檢測噁性腫瘤患者化療期間骨髓造血功能抑製和恢複的早期敏感指標。
목적：탐토악성종류병인화료과정중미성숙망직홍세포지수（IRF）화상관삼수적변화급기림상의의。방법：채용Sysmex XN-9000전자동혈세포분석의대51례악성종류환자화료전후외주혈미성숙망직홍세포지수(IRF)、망직홍세포백분수（Ret%）、백세포계수(WBC)화혈소판계수（PLT）진행동태검측。결과：화료후제3천， IRF화Ret%출현명현하강，차이유통계학의의（Р<0.01），IRF제6천강도최저，제10천유소회승，Ret%제10천강도최저，제15천IRF화Ret%명현상승，차이유통계학의의（Р<0.01）；WBC화PLT재화료후제6천출현명현하강，차이유통계학의의（Р<0.01），제15천강도최저，제20천교제15천출현상승，차이유통계학의의(Р<0.05)。결론：미성숙망직홍세포지수급상관삼수가작위검측악성종류환자화료기간골수조혈공능억제화회복적조기민감지표。
Objective:To explore the clinical significance of the changes in immature reticulocyte fraction and related parameters in malignant tumor patients during chemotherapy.Methods:The dgnamic changes of the immature reticulocyte fraction (IRF),the percentage of reticulocyte (Ret%),white blood cell count(WBC) and platelet count(PLT) of peripheral bloods were detected by Sysmex XN-9000 automatic blood cell analyzer before and after chemotherapy in 51 cases of malignant tumor patients.Results:Compared with the value before chemotherapy, IRF and Ret% decreased dramatically on the 3rd day after chemotherapy, the difference was statistically significant (P<0.01). IRF was the lowest on the 6th day and rebounded gradually on the 10th day. Ret% was the lowest on the 10th day. And IRF and Ret% increased significantly on the 15th day (P<0.01). WBC and PLT decreased significantly on the 6th day(P<0.01). Both of them were the lowest on the 15th day and rebounded gradually on the 20th day compared with those on the 15th day (P<0.01).Conclusions: IRF and related parameters can be served as early and sensitive predictive indicators in monitoring the suppression and recovery of bone marrow function in patients with malignant tumor during the chemotherapy.
